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Referee comments: Referee 1

Posted by PLOS_ONE_Group on 03 Mar 2008 at 11:38 GMT

Referee 1's review:

The data presented are very important extend the previously published data which demonstrated cross-reactivity against clade 2.1 viruses. It would be useful if the authors also include the titers gainst homologous strain, A/VN/1194/04 in the panel to give the reader a complete picture. The cross-reactive antibody titers against clade 2 viruses decline at 6 months post-booster dose. Do antibody titers against homologous virus also follow the same trend?

Page 5 line 15. US FDA approved the H5N1 vaccine and not licensed it. Authors, please change licensed to approved.

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N.B. These are the comments made by the referee when reviewing an earlier version of this paper. Prior to publication the manuscript has been revised in light of these comments and to address other editorial requirements.