Recurrent, Robust and Scalable Patterns Underlie Human Approach and Avoidance

• Byoung Woo Kim ,

  Contributed equally to this work with: Byoung Woo Kim, Hans C. Breiter

  Affiliations Motivation and Emotion Neuroscience Collaboration (MENC), Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Laboratory of Neuroimaging and Genetics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• David N. Kennedy ,

  ¶These authors also contributed equally to this work.

  Affiliation Center for Morphometric Analysis, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Joseph Lehár ,

  ¶These authors also contributed equally to this work.

  Affiliation Department of Bioinformatics, Boston University, Boston, Massachusetts, United States of America

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• Myung Joo Lee ,

  ¶These authors also contributed equally to this work.

  Affiliations Motivation and Emotion Neuroscience Collaboration (MENC), Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Laboratory of Neuroimaging and Genetics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Anne J. Blood ,

  ¶These authors also contributed equally to this work.

  Affiliations Motivation and Emotion Neuroscience Collaboration (MENC), Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Laboratory of Neuroimaging and Genetics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Mood and Motor Control Laboratory, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Sang Lee ,

  ¶These authors also contributed equally to this work.

  Affiliations Motivation and Emotion Neuroscience Collaboration (MENC), Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Laboratory of Neuroimaging and Genetics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Roy H. Perlis,

  Affiliations Depression Clinic and Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Psychiatric and Neurodevelopmental Genetics Unit of the Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Jordan W. Smoller,

  Affiliation Psychiatric and Neurodevelopmental Genetics Unit of the Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Robert Morris,

  Affiliation Motivation and Emotion Neuroscience Collaboration (MENC), Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Maurizio Fava,

  Affiliation Depression Clinic and Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Hans C. Breiter ,

  Contributed equally to this work with: Byoung Woo Kim, Hans C. Breiter

  * E-mail: hbreiter@partners.org

  Affiliations Motivation and Emotion Neuroscience Collaboration (MENC), Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Laboratory of Neuroimaging and Genetics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Mood and Motor Control Laboratory, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• for the Phenotype Genotype Project in Addiction and Mood Disorders (PGP)