Ultrastructural Proof of Polyomavirus in Merkel Cell Carcinoma Tumour Cells and Its Absence in Small Cell Carcinoma of the Lung

Charlotte T. A. H. Wetzels; Jolanda G. M. Hoefnagel; Judith M. J. E. Bakkers; Henry B. P. M. Dijkman; Willeke A. M. Blokx; Willem J. G. Melchers

doi:10.1371/journal.pone.0004958

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Open Access

Peer-reviewed

Research Article

Ultrastructural Proof of Polyomavirus in Merkel Cell Carcinoma Tumour Cells and Its Absence in Small Cell Carcinoma of the Lung

Charlotte T. A. H. Wetzels ,

Contributed equally to this work with: Charlotte T. A. H. Wetzels, Jolanda G. M. Hoefnagel

* E-mail: C.Wetzels@pathol.umcn.nl

Affiliation Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
⨯
Jolanda G. M. Hoefnagel ,

Contributed equally to this work with: Charlotte T. A. H. Wetzels, Jolanda G. M. Hoefnagel

Affiliation Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
⨯
Judith M. J. E. Bakkers,

Affiliation Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
⨯
Henry B. P. M. Dijkman,

Affiliation Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
⨯
Willeke A. M. Blokx,

Affiliation Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
⨯
Willem J. G. Melchers

Affiliation Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
⨯

Ultrastructural Proof of Polyomavirus in Merkel Cell Carcinoma Tumour Cells and Its Absence in Small Cell Carcinoma of the Lung

Charlotte T. A. H. Wetzels,
Jolanda G. M. Hoefnagel,
Judith M. J. E. Bakkers,
Henry B. P. M. Dijkman,
Willeke A. M. Blokx,
Willem J. G. Melchers

Published: March 23, 2009
https://doi.org/10.1371/journal.pone.0004958

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Caution

Posted by HPVPyV on 26 Mar 2009 at 20:40 GMT

For me, datas concerning the presence of virus particles in mcc are not convincing on the base on these micrographs.
The low percentage of MCV detection is not supported by the variability of the virus since many other studies have largeky higher percentages of detection of mcv in mcc.
Classification of viruses is not up to date since papovaviridae does not exist today.

No competing interests declared.

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Ultrastructural Proof of Polyomavirus in Merkel Cell Carcinoma Tumour Cells and Its Absence in Small Cell Carcinoma of the Lung

Ultrastructural Proof of Polyomavirus in Merkel Cell Carcinoma Tumour Cells and Its Absence in Small Cell Carcinoma of the Lung

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Caution

Posted by HPVPyV on 26 Mar 2009 at 20:40 GMT