Altered Chromosomal Positioning, Compaction, and Gene Expression with a Lamin A/C Gene Mutation

Stephanie K. Mewborn; Megan J. Puckelwartz; Fida Abuisneineh; John P. Fahrenbach; Yuan Zhang; Heather MacLeod; Lisa Dellefave; Peter Pytel; Sara Selig; Christine M. Labno; Karen Reddy; Harinder Singh; Elizabeth McNally

doi:10.1371/journal.pone.0014342

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Research Article

Altered Chromosomal Positioning, Compaction, and Gene Expression with a Lamin A/C Gene Mutation

Stephanie K. Mewborn ,

Contributed equally to this work with: Stephanie K. Mewborn, Megan J. Puckelwartz

Affiliation Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯
Megan J. Puckelwartz ,

Contributed equally to this work with: Stephanie K. Mewborn, Megan J. Puckelwartz

Affiliations Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America, Department of Human Genetics, The University of Chicago, Chicago, Illinois, United States of America
⨯
Fida Abuisneineh,

Affiliation Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯
John P. Fahrenbach,

Affiliation Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯
Yuan Zhang,

Affiliation Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯
Heather MacLeod,

Affiliation Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯
Lisa Dellefave,

Affiliation Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯
Peter Pytel,

Affiliation Department of Pathology, The University of Chicago, Chicago, Illinois, United States of America
⨯
Sara Selig,

Affiliation Molecular Medicine Laboratory, Rambam Health Care Campus and Rappaport Faculty of Medicine and Research Institute, Technion - Israel Institute of Technology, Haifa, Israel
⨯
Christine M. Labno,

Affiliation Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯
Karen Reddy,

Current address: School of Medicine, Johns Hopkins, Baltimore, Maryland, United States of America

Affiliation Howard Hughes Medical Institute and Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois, United States of America
⨯
Harinder Singh,

Affiliation Howard Hughes Medical Institute and Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois, United States of America
⨯
Elizabeth McNally

* E-mail: emcnally@uchicago.edu

Affiliations Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America, Department of Human Genetics, The University of Chicago, Chicago, Illinois, United States of America
⨯

Altered Chromosomal Positioning, Compaction, and Gene Expression with a Lamin A/C Gene Mutation

Stephanie K. Mewborn,
Megan J. Puckelwartz,
Fida Abuisneineh,
John P. Fahrenbach,
Yuan Zhang,
Heather MacLeod,
Lisa Dellefave,
Peter Pytel,
Sara Selig,
Christine M. Labno

Published: December 14, 2010
https://doi.org/10.1371/journal.pone.0014342

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Publisher's Note: Update to Table 1.

Posted by PLOS_ONE_Group on 10 Jul 2012 at 22:16 GMT

Genes
http://plosone.org/article/info:doi/10.1371/journal.pone.0014342#pone-0014342-t001

The original table contains an error in row 30. The heart microarray fold change is stated as 4.8 for LMO7, the table should read -4.8 fold change. This typographical error is not propagated throughout the rest of the paper and does not change the conclusions. Both the text and Table 2 state that LMO7 is down-regulated in the LMNA E161K heart relative to the control heart, which is accurate. The updated version of Table 1 can be seen here: http://www.plosone.org/corrections/pone.0014342.t001.cn.docx [^]

No competing interests declared.

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Altered Chromosomal Positioning, Compaction, and Gene Expression with a Lamin A/C Gene Mutation

Altered Chromosomal Positioning, Compaction, and Gene Expression with a Lamin A/C Gene Mutation

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Publisher's Note: Update to Table 1.

Posted by PLOS_ONE_Group on 10 Jul 2012 at 22:16 GMT