A Pilot Study Using Next-Generation Sequencing in Advanced Cancers: Feasibility and Challenges

Glen J. Weiss; Winnie S. Liang; Michael J. Demeure; Jeff A. Kiefer; Galen Hostetter; Tyler Izatt; Shripad Sinari; Alexis Christoforides; Jessica Aldrich; Ahmet Kurdoglu; Lori Phillips; Hollie Benson; Rebecca Reiman; Angela Baker; Vickie Marsh; Daniel D. Von Hoff; John D. Carpten; David W. Craig

doi:10.1371/journal.pone.0076438

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Peer-reviewed

Research Article

A Pilot Study Using Next-Generation Sequencing in Advanced Cancers: Feasibility and Challenges

Glen J. Weiss ,

* E-mail: glen.weiss@ctca-hope.com

Affiliations Virginia G. Piper Cancer Center Clinical Trials at Scottsdale Healthcare (VGPCC), Scottsdale, Arizona, United States of America, The Translational Genomics Research Institute, Phoenix, Arizona, United States of America
⨯
Winnie S. Liang,

Affiliation The Translational Genomics Research Institute, Phoenix, Arizona, United States of America
⨯
Michael J. Demeure,

Affiliations Virginia G. Piper Cancer Center Clinical Trials at Scottsdale Healthcare (VGPCC), Scottsdale, Arizona, United States of America, The Translational Genomics Research Institute, Phoenix, Arizona, United States of America
⨯
Jeff A. Kiefer,

Affiliation The Translational Genomics Research Institute, Phoenix, Arizona, United States of America
⨯
Galen Hostetter,

Affiliations The Translational Genomics Research Institute, Phoenix, Arizona, United States of America, Van Andel Research Institute, Grand Rapids, Michigan, United States of America
⨯
Tyler Izatt,

Affiliation The Translational Genomics Research Institute, Phoenix, Arizona, United States of America
⨯
Shripad Sinari,

Affiliation The Translational Genomics Research Institute, Phoenix, Arizona, United States of America
⨯
Alexis Christoforides,

Affiliation The Translational Genomics Research Institute, Phoenix, Arizona, United States of America
⨯
Jessica Aldrich,

Affiliation The Translational Genomics Research Institute, Phoenix, Arizona, United States of America
⨯
Ahmet Kurdoglu,

Affiliation The Translational Genomics Research Institute, Phoenix, Arizona, United States of America
⨯
Lori Phillips,

Affiliation The Translational Genomics Research Institute, Phoenix, Arizona, United States of America
⨯
Hollie Benson,

Affiliation The Translational Genomics Research Institute, Phoenix, Arizona, United States of America
⨯
Rebecca Reiman,

Affiliation The Translational Genomics Research Institute, Phoenix, Arizona, United States of America
⨯
Angela Baker,

Affiliation The Translational Genomics Research Institute, Phoenix, Arizona, United States of America
⨯
Vickie Marsh,

Affiliation Virginia G. Piper Cancer Center Clinical Trials at Scottsdale Healthcare (VGPCC), Scottsdale, Arizona, United States of America
⨯
Daniel D. Von Hoff ,

Contributed equally to this work with: Daniel D. Von Hoff, John D. Carpten, David W. Craig

Affiliations Virginia G. Piper Cancer Center Clinical Trials at Scottsdale Healthcare (VGPCC), Scottsdale, Arizona, United States of America, The Translational Genomics Research Institute, Phoenix, Arizona, United States of America
⨯
John D. Carpten ,

Contributed equally to this work with: Daniel D. Von Hoff, John D. Carpten, David W. Craig

Affiliation The Translational Genomics Research Institute, Phoenix, Arizona, United States of America
⨯
[ ... ],
David W. Craig

Contributed equally to this work with: Daniel D. Von Hoff, John D. Carpten, David W. Craig

Affiliation The Translational Genomics Research Institute, Phoenix, Arizona, United States of America
⨯
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A Pilot Study Using Next-Generation Sequencing in Advanced Cancers: Feasibility and Challenges

Glen J. Weiss,
Winnie S. Liang,
Michael J. Demeure,
Jeff A. Kiefer,
Galen Hostetter,
Tyler Izatt,
Shripad Sinari,
Alexis Christoforides,
Jessica Aldrich,
Ahmet Kurdoglu

Published: October 30, 2013
https://doi.org/10.1371/journal.pone.0076438

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 01 Nov 2013 at 20:50 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: Drug Discovery and Development
Title: “Fast Genetic Analysis Uncovers New Drug Targets”
http://www.dddmag.com/new...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS ONE Staff

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A Pilot Study Using Next-Generation Sequencing in Advanced Cancers: Feasibility and Challenges

A Pilot Study Using Next-Generation Sequencing in Advanced Cancers: Feasibility and Challenges

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 01 Nov 2013 at 20:50 GMT