Erythropoietin: A Potent Inducer of Peripheral Immuno/Inflammatory Modulation in Autoimmune EAE

RuiRong Yuan; Yasuhiro Maeda; Weiping Li; Wei Lu; Stuart Cook; Peter Dowling

doi:10.1371/journal.pone.0001924

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Peer-reviewed

Research Article

Erythropoietin: A Potent Inducer of Peripheral Immuno/Inflammatory Modulation in Autoimmune EAE

RuiRong Yuan,

Affiliations Department of Veterans Affairs, New Jersey Health Care System, East Orange, New Jersey, United States of America, Department of Neurosciences and Neurology, UMDNJ-New Jersey Medical School, Newark, New Jersey, United States of America
⨯
Yasuhiro Maeda,

Affiliations Department of Veterans Affairs, New Jersey Health Care System, East Orange, New Jersey, United States of America, Department of Neurosciences and Neurology, UMDNJ-New Jersey Medical School, Newark, New Jersey, United States of America
⨯
Weiping Li,

Affiliation Department of Veterans Affairs, New Jersey Health Care System, East Orange, New Jersey, United States of America
⨯
Wei Lu,

Affiliation Department of Veterans Affairs, New Jersey Health Care System, East Orange, New Jersey, United States of America
⨯
Stuart Cook,

Affiliations Department of Veterans Affairs, New Jersey Health Care System, East Orange, New Jersey, United States of America, Department of Neurosciences and Neurology, UMDNJ-New Jersey Medical School, Newark, New Jersey, United States of America
⨯
Peter Dowling

* E-mail: dowlinpc@umdnj.edu

Affiliations Department of Veterans Affairs, New Jersey Health Care System, East Orange, New Jersey, United States of America, Department of Neurosciences and Neurology, UMDNJ-New Jersey Medical School, Newark, New Jersey, United States of America
⨯

Erythropoietin: A Potent Inducer of Peripheral Immuno/Inflammatory Modulation in Autoimmune EAE

RuiRong Yuan,
Yasuhiro Maeda,
Weiping Li,
Wei Lu,
Stuart Cook,
Peter Dowling

Published: April 2, 2008
https://doi.org/10.1371/journal.pone.0001924

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STAT5

Posted by marodon on 24 Oct 2008 at 07:54 GMT

The mechanism and precise signaling pathway by which EPO suppresses the immune response in the peripheral lymphoid tissues is also unknown
http://plosone.org/article/info:doi/10.1371/journal.pone.0001924#article1.body1.sec3.p7

STAT5 likely involved here since it is a positive regulator of foxp3 expression and EPO signals through STAT5 phosphorylation.

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Erythropoietin: A Potent Inducer of Peripheral Immuno/Inflammatory Modulation in Autoimmune EAE

Erythropoietin: A Potent Inducer of Peripheral Immuno/Inflammatory Modulation in Autoimmune EAE

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STAT5

Posted by marodon on 24 Oct 2008 at 07:54 GMT