Simulated Impact of RTS,S/AS01 Vaccination Programs in the Context of Changing Malaria Transmission

Alan Brooks; Olivier J. T. Briët; Diggory Hardy; Richard Steketee; Thomas A. Smith

doi:10.1371/journal.pone.0032587

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Open Access

Peer-reviewed

Research Article

Simulated Impact of RTS,S/AS01 Vaccination Programs in the Context of Changing Malaria Transmission

Alan Brooks ,

* E-mail: Alan.Brooks@unibas.ch

Affiliations Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland
⨯
Olivier J. T. Briët,

Affiliations Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland
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Diggory Hardy,

Affiliations Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland
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Richard Steketee,

Affiliation Malaria Control and Evaluation Partnership for Africa, PATH, Seattle, Washington, United States of America
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Thomas A. Smith

Affiliations Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland
⨯

Simulated Impact of RTS,S/AS01 Vaccination Programs in the Context of Changing Malaria Transmission

Alan Brooks,
Olivier J. T. Briët,
Diggory Hardy,
Richard Steketee,
Thomas A. Smith

Published: March 6, 2012
https://doi.org/10.1371/journal.pone.0032587

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Clive Shiff

Posted by CliveShiff on 09 Mar 2012 at 18:54 GMT

I read this with interest, but ask as a caveat why you imply reductions to the EIR should be included. As the cut off for clinical malaria as decided in the scope of work still accepts significant parasitaemia, one cannot assume that transmission will be reduced. As such EIR should be left constant, in which case my comment wouldnt the 3 billion be better spent on reducing transmission, as we have an excellent drug and mortality due to malaria can easily and cheaply be reduced to low levels.

No competing interests declared.

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Vaccination and immunization
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Malaria
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Infants
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Simulated Impact of RTS,S/AS01 Vaccination Programs in the Context of Changing Malaria Transmission

Simulated Impact of RTS,S/AS01 Vaccination Programs in the Context of Changing Malaria Transmission

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Clive Shiff

Posted by CliveShiff on 09 Mar 2012 at 18:54 GMT