Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism

Sebastiano Collino; Ivan Montoliu; François-Pierre J. Martin; Max Scherer; Daniela Mari; Stefano Salvioli; Laura Bucci; Rita Ostan; Daniela Monti; Elena Biagi; Patrizia Brigidi; Claudio Franceschi; Serge Rezzi

doi:10.1371/journal.pone.0056564

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Research Article

Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism

Sebastiano Collino ,

* E-mail: sebastiano.collino@rd.nestle.com

Affiliation Proteomics and Metabonomics, Nestlé Institute of Health Sciences SA, Campus EPFL, Quartier de l'innovation, Lausanne, Switzerland
⨯
Ivan Montoliu,

Affiliation Applied Mathematics, NESTEC SA, Nestlé Research Center, Lausanne, Switzerland
⨯
François-Pierre J. Martin,

Affiliation Proteomics and Metabonomics, Nestlé Institute of Health Sciences SA, Campus EPFL, Quartier de l'innovation, Lausanne, Switzerland
⨯
Max Scherer,

Affiliation Proteomics and Metabonomics, Nestlé Institute of Health Sciences SA, Campus EPFL, Quartier de l'innovation, Lausanne, Switzerland
⨯
Daniela Mari,

Affiliations Department of Medical Sciences, University of Milan, Milan, Italy, Geriatric Unit Ca' Grande Foundation Maggiore Policlinico Hospital, Milan, Italy
⨯
Stefano Salvioli,

Affiliations Department of Experimental Pathology, University of Bologna, Bologna, Italy, Interdepartmental Centre L. Galvani, University of Bologna, Bologna, Italy
⨯
Laura Bucci,

Affiliations Department of Experimental Pathology, University of Bologna, Bologna, Italy, Interdepartmental Centre L. Galvani, University of Bologna, Bologna, Italy
⨯
Rita Ostan,

Affiliations Department of Experimental Pathology, University of Bologna, Bologna, Italy, Interdepartmental Centre L. Galvani, University of Bologna, Bologna, Italy
⨯
Daniela Monti,

Affiliation Department of Experimental Pathology and Oncology, University of Florence, Florence, Italy
⨯
Elena Biagi,

Affiliation Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy
⨯
Patrizia Brigidi,

Affiliation Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy
⨯
Claudio Franceschi,

Affiliations Department of Experimental Pathology, University of Bologna, Bologna, Italy, Interdepartmental Centre L. Galvani, University of Bologna, Bologna, Italy
⨯
Serge Rezzi

Affiliation Proteomics and Metabonomics, Nestlé Institute of Health Sciences SA, Campus EPFL, Quartier de l'innovation, Lausanne, Switzerland
⨯

Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism

Sebastiano Collino,
Ivan Montoliu,
François-Pierre J. Martin,
Max Scherer,
Daniela Mari,
Stefano Salvioli,
Laura Bucci,
Rita Ostan,
Daniela Monti,
Elena Biagi

Published: March 6, 2013
https://doi.org/10.1371/journal.pone.0056564

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 15 Mar 2013 at 18:32 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: Real Clear Science
Title: “The Metabolic Signature of Really Old People”
http://www.realclearscien...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS One Staff

Media Coverage of This Article

PLOS_ONE_Group replied to PLOS_ONE_Group on 24 Sep 2013 at 16:13 GMT

The following articles represent some of the media coverage that has occurred for this paper:

Publication: MarketWatch
Title: “Nestle research identifies metabolic signature for long life - MarketWatch”
http://www.marketwatch.co...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS ONE Staff

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Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism

Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 15 Mar 2013 at 18:32 GMT

Media Coverage of This Article

PLOS_ONE_Group replied to PLOS_ONE_Group on 24 Sep 2013 at 16:13 GMT