A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

Jamie L. Barger; Tsuyoshi Kayo; James M. Vann; Edward B. Arias; Jelai Wang; Timothy A. Hacker; Ying Wang; Daniel Raederstorff; Jason D. Morrow; Christiaan Leeuwenburgh; David B. Allison; Kurt W. Saupe; Gregory D. Cartee; Richard Weindruch; Tomas A. Prolla

doi:10.1371/journal.pone.0002264

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Open Access

Peer-reviewed

Research Article

A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

Jamie L. Barger,

Affiliation LifeGen Technologies, LLC, Madison, Wisconsin, United States of America
⨯
Tsuyoshi Kayo,

Affiliation LifeGen Technologies, LLC, Madison, Wisconsin, United States of America
⨯
James M. Vann,

Affiliations Department of Medical Genetics, University of Wisconsin, Madison, Wisconsin, United States of America, Department of Genetics, University of Wisconsin, Madison, Wisconsin, United States of America
⨯
Edward B. Arias,

Affiliation Division of Kinesiology, University of Michigan, Ann Arbor, Michigan, United States of America
⨯
Jelai Wang,

Affiliation Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Timothy A. Hacker,

Affiliation Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Ying Wang,

Affiliation R&D Human Nutrition and Health, DSM Nutritional Products Ltd., Basel, Switzerland
⨯
Daniel Raederstorff,

Affiliation R&D Human Nutrition and Health, DSM Nutritional Products Ltd., Basel, Switzerland
⨯
Jason D. Morrow,

Affiliations Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Christiaan Leeuwenburgh,

Affiliation Department of Aging and Geriatrics and College of Medicine, University of Florida, Gainesville, Florida, United States of America
⨯
David B. Allison,

Affiliation Section on Statistical Genetics, Department of Biostatistics and Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Kurt W. Saupe,

Affiliation Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Gregory D. Cartee,

Affiliation Division of Kinesiology, University of Michigan, Ann Arbor, Michigan, United States of America
⨯
Richard Weindruch ,

* E-mail: rhweindr@wisc.edu (RW); taprolla@wisc.edu (TP)

Affiliation Department of Medicine and Veterans Administration Hospital, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Tomas A. Prolla

* E-mail: rhweindr@wisc.edu (RW); taprolla@wisc.edu (TP)

Affiliations Department of Medical Genetics, University of Wisconsin, Madison, Wisconsin, United States of America, Department of Genetics, University of Wisconsin, Madison, Wisconsin, United States of America
⨯

A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

Jamie L. Barger,
Tsuyoshi Kayo,
James M. Vann,
Edward B. Arias,
Jelai Wang,
Timothy A. Hacker,
Ying Wang,
Daniel Raederstorff,
Jason D. Morrow,
Christiaan Leeuwenburgh

Published: June 4, 2008
https://doi.org/10.1371/journal.pone.0002264

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Further to the study

Posted by Cole01 on 19 Jun 2008 at 21:04 GMT

1. Was any difference in epidermal elasticity noted, such as collagen retention? In short, were there external differences to be noted that would arguably point to longevity of epidermal tissue integrity?
2. Would there be any benefit to replicating the study w/a fourth group, treated w/combination resveratrol & CR (from 10% to 30%), or would they necessarily cancel each other out?
3. Was there any appreciable difference in muscle recovery under CR or resveratrol?

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A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

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Further to the study

Posted by Cole01 on 19 Jun 2008 at 21:04 GMT