Neural Stem/Progenitor Cells from the Adult Human Spinal Cord Are Multipotent and Self-Renewing and Differentiate after Transplantation

Andrea J. Mothe; Tasneem Zahir; Carlo Santaguida; Douglas Cook; Charles H. Tator

doi:10.1371/journal.pone.0027079

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Open Access

Peer-reviewed

Research Article

Neural Stem/Progenitor Cells from the Adult Human Spinal Cord Are Multipotent and Self-Renewing and Differentiate after Transplantation

Andrea J. Mothe ,

* E-mail: amothe@uhnres.utoronto.ca

Affiliation Division of Genetics and Development, Toronto Western Research Institute and Krembil Neuroscience Centre, Toronto Western Hospital, Toronto, Ontario, Canada
⨯
Tasneem Zahir,

Affiliation Division of Genetics and Development, Toronto Western Research Institute and Krembil Neuroscience Centre, Toronto Western Hospital, Toronto, Ontario, Canada
⨯
Carlo Santaguida,

Affiliation Division of Genetics and Development, Toronto Western Research Institute and Krembil Neuroscience Centre, Toronto Western Hospital, Toronto, Ontario, Canada
⨯
Douglas Cook,

Affiliation Division of Genetics and Development, Toronto Western Research Institute and Krembil Neuroscience Centre, Toronto Western Hospital, Toronto, Ontario, Canada
⨯
Charles H. Tator

Affiliation Division of Genetics and Development, Toronto Western Research Institute and Krembil Neuroscience Centre, Toronto Western Hospital, Toronto, Ontario, Canada
⨯

Neural Stem/Progenitor Cells from the Adult Human Spinal Cord Are Multipotent and Self-Renewing and Differentiate after Transplantation

Andrea J. Mothe,
Tasneem Zahir,
Carlo Santaguida,
Douglas Cook,
Charles H. Tator

Published: November 2, 2011
https://doi.org/10.1371/journal.pone.0027079

Reader Comments

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2-yr-old donor

Posted by waisi on 30 Nov 2011 at 15:50 GMT

Hello. Nice and informative study!

Just wondering why you included spinal cord tissue from a 2-yr-old donor in your adult spinal cord NSPC study?

Thanks.

No competing interests declared.

RE: 2-yr-old donor

amothe replied to waisi on 01 Dec 2011 at 15:35 GMT

Thank you!
We had considered this and in the end decided to include the data. The phenotypic profile is different so we show this as a separate graph from the adult donors.
Thank you for your interest.

No competing interests declared.

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Neural Stem/Progenitor Cells from the Adult Human Spinal Cord Are Multipotent and Self-Renewing and Differentiate after Transplantation

Neural Stem/Progenitor Cells from the Adult Human Spinal Cord Are Multipotent and Self-Renewing and Differentiate after Transplantation

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2-yr-old donor

Posted by waisi on 30 Nov 2011 at 15:50 GMT

RE: 2-yr-old donor

amothe replied to waisi on 01 Dec 2011 at 15:35 GMT