Environmental Enrichment Extends Photoreceptor Survival and Visual Function in a Mouse Model of Retinitis Pigmentosa

Ilaria Barone; Elena Novelli; Ilaria Piano; Claudia Gargini; Enrica Strettoi

doi:10.1371/journal.pone.0050726

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Peer-reviewed

Research Article

Environmental Enrichment Extends Photoreceptor Survival and Visual Function in a Mouse Model of Retinitis Pigmentosa

Ilaria Barone,

Affiliation Neuroscience Institute, Italian National Research Council (CNR), Pisa, Italy
⨯
Elena Novelli,

Affiliation G.B. Bietti Foundation for Ophthalmology, Rome, Italy
⨯
Ilaria Piano,

Affiliation G.B. Bietti Foundation for Ophthalmology, Rome, Italy
⨯
Claudia Gargini,

Affiliation Department of Pharmacy, University of Pisa, Pisa, Italy
⨯
Enrica Strettoi

* E-mail: enrica.strettoi@in.cnr.it

Affiliation Neuroscience Institute, Italian National Research Council (CNR), Pisa, Italy
⨯

Environmental Enrichment Extends Photoreceptor Survival and Visual Function in a Mouse Model of Retinitis Pigmentosa

Ilaria Barone,
Elena Novelli,
Ilaria Piano,
Claudia Gargini,
Enrica Strettoi

Published: November 28, 2012
https://doi.org/10.1371/journal.pone.0050726

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Blue light blocked by plastic? not controlled for?

Posted by kpmitton on 15 Dec 2012 at 15:57 GMT

My only suggestion is that plastic blocks most far blue and uv light in the spectrum that would accelerate degeneration in a model like this.

This should be discounted by doing the same experiment in 24 hr darkness rearing. Without that control I am not yet convinced. I have an open mind, but I am not convinced yet.

Competing interests declared: I use the rd10 model but enrichment effects are not my area of investigation and would not concern me should it be true or not.

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Environmental Enrichment Extends Photoreceptor Survival and Visual Function in a Mouse Model of Retinitis Pigmentosa

Environmental Enrichment Extends Photoreceptor Survival and Visual Function in a Mouse Model of Retinitis Pigmentosa

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Blue light blocked by plastic? not controlled for?

Posted by kpmitton on 15 Dec 2012 at 15:57 GMT