Efficient Conversion of Astrocytes to Functional Midbrain Dopaminergic Neurons Using a Single Polycistronic Vector

Russell C. Addis; Fu-Chun Hsu; Rebecca L. Wright; Marc A. Dichter; Douglas A. Coulter; John D. Gearhart

doi:10.1371/journal.pone.0028719

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Peer-reviewed

Research Article

Efficient Conversion of Astrocytes to Functional Midbrain Dopaminergic Neurons Using a Single Polycistronic Vector

Russell C. Addis ,

* E-mail: raddis@mail.med.upenn.edu

Affiliation Institute for Regenerative Medicine and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Fu-Chun Hsu,

Affiliation Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Rebecca L. Wright,

Affiliation Institute for Regenerative Medicine and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Marc A. Dichter,

Affiliations Mahoney Institute of Neurological Sciences, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Douglas A. Coulter,

Affiliations Mahoney Institute of Neurological Sciences, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Departments of Pediatrics and Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
John D. Gearhart

Affiliation Institute for Regenerative Medicine and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯

Efficient Conversion of Astrocytes to Functional Midbrain Dopaminergic Neurons Using a Single Polycistronic Vector

Russell C. Addis,
Fu-Chun Hsu,
Rebecca L. Wright,
Marc A. Dichter,
Douglas A. Coulter,
John D. Gearhart

Published: December 9, 2011
https://doi.org/10.1371/journal.pone.0028719

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Posted by PLOS_ONE_Group on 16 Dec 2011 at 21:34 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: University of Pennsylvania
Title: “Reprogramming Brain Cells Important First Step for New Parkinson's Therapy, Penn Study Finds”
http://www.uphs.upenn.edu...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLoS ONE Staff

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Efficient Conversion of Astrocytes to Functional Midbrain Dopaminergic Neurons Using a Single Polycistronic Vector

Efficient Conversion of Astrocytes to Functional Midbrain Dopaminergic Neurons Using a Single Polycistronic Vector

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 16 Dec 2011 at 21:34 GMT