BRCAness Profile of Sporadic Ovarian Cancer Predicts Disease Recurrence

Weiya Z. Wysham; Paulette Mhawech-Fauceglia; Hong Li; Laura Hays; Suzanna Syriac; Tijana Skrepnik; Jay Wright; Nupur Pande; Maureen Hoatlin; Tanja Pejovic

doi:10.1371/journal.pone.0030042

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Open Access

Peer-reviewed

Research Article

BRCAness Profile of Sporadic Ovarian Cancer Predicts Disease Recurrence

Weiya Z. Wysham,

Affiliations Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon, United States of America, Knight Cancer Institute, Portland, Oregon, United States of America
⨯
Paulette Mhawech-Fauceglia,

Affiliation Department of Pathology, Roswell Park Cancer Institute, Buffalo, New York, United States of America
⨯
Hong Li,

Affiliation Department of Biostatistics, Oregon Health & Science University, Knight Cancer Institute, Portland, Oregon, United States of America
⨯
Laura Hays,

Affiliation Knight Cancer Institute, Portland, Oregon, United States of America
⨯
Suzanna Syriac,

Affiliation Department of Pathology, Roswell Park Cancer Institute, Buffalo, New York, United States of America
⨯
Tijana Skrepnik,

Affiliation University of Arizona, Tucson, Arizona, United States of America
⨯
Jay Wright,

Affiliation Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon, United States of America
⨯
Nupur Pande,

Affiliations Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon, United States of America, Knight Cancer Institute, Portland, Oregon, United States of America
⨯
Maureen Hoatlin,

Affiliations Knight Cancer Institute, Portland, Oregon, United States of America, Department of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland, Oregon, United States of America
⨯
Tanja Pejovic

* E-mail: pejovict@ohsu.edu

Affiliations Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon, United States of America, Knight Cancer Institute, Portland, Oregon, United States of America
⨯

BRCAness Profile of Sporadic Ovarian Cancer Predicts Disease Recurrence

Weiya Z. Wysham,
Paulette Mhawech-Fauceglia,
Hong Li,
Laura Hays,
Suzanna Syriac,
Tijana Skrepnik,
Jay Wright,
Nupur Pande,
Maureen Hoatlin,
Tanja Pejovic

Published: January 11, 2012
https://doi.org/10.1371/journal.pone.0030042

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serous vs non serous

Posted by cecilelepage on 18 Jan 2012 at 21:48 GMT

37 (22%) with overexpression of all 3 proteins
http://plosone.org/article/info:doi/10.1371/journal.pone.0030042#article1.body1.sec3.sec2.p1

serous and non-serous patients should be indicated since each histopathology is associated with different prognosis and molecular profiling

No competing interests declared.

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Genetic causes of cancer
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Ovarian cancer
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Cancer treatment
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DNA repair
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Breast cancer
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Platinum
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BRCAness Profile of Sporadic Ovarian Cancer Predicts Disease Recurrence

BRCAness Profile of Sporadic Ovarian Cancer Predicts Disease Recurrence

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serous vs non serous

Posted by cecilelepage on 18 Jan 2012 at 21:48 GMT