Evaluation of Genetic Mutations Associated with Mycobacterium tuberculosis Resistance to Amikacin, Kanamycin and Capreomycin: A Systematic Review

Open Access

Peer-reviewed

Research Article

Sophia B. Georghiou,

Affiliation Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Marisa Magana,

Affiliation University of California San Diego Medical Center, San Diego, California, United States of America
⨯
Richard S. Garfein,

Affiliation Division of Global Public Health, University of California San Diego School of Medicine, La Jolla, California, United States of America
⨯
Donald G. Catanzaro,

Affiliation Department of Family and Preventive Medicine, University of California San Diego Health Services Research Center, La Jolla, California, United States of America
⨯
Antonino Catanzaro,

Affiliation University of California San Diego Medical Center, San Diego, California, United States of America
⨯
Timothy C. Rodwell

* E-mail: trodwell@ucsd.edu

Affiliation Division of Global Public Health, University of California San Diego School of Medicine, La Jolla, California, United States of America
⨯

Reader Comments

none had any mutations within the tlyA gene.
http://plosone.org/article/info:doi/10.1371/journal.pone.0033275#article1.body1.sec3.sec3.p1

None of the CAP susceptible strains evaluated had any resistance-related mutations within the tlyA gene. Some studies did report rare tlyA mutations that have only been found in CAP susceptible strains.

No competing interests declared.

Mutation
Is the Subject Area "Mutation" applicable to this article?

Thanks for your feedback.
Mycobacterium tuberculosis
Is the Subject Area "Mycobacterium tuberculosis" applicable to this article?

Thanks for your feedback.
Mutation detection
Is the Subject Area "Mutation detection" applicable to this article?

Thanks for your feedback.
Extensively drug-resistant tuberculosis
Is the Subject Area "Extensively drug-resistant tuberculosis" applicable to this article?

Thanks for your feedback.
Insertion mutation
Is the Subject Area "Insertion mutation" applicable to this article?

Thanks for your feedback.
Point mutation
Is the Subject Area "Point mutation" applicable to this article?

Thanks for your feedback.
Tuberculosis
Is the Subject Area "Tuberculosis" applicable to this article?

Thanks for your feedback.
Multi-drug-resistant tuberculosis
Is the Subject Area "Multi-drug-resistant tuberculosis" applicable to this article?

Thanks for your feedback.