Characterization of a Natural Mutator Variant of Human DNA Polymerase λ which Promotes Chromosomal Instability by Compromising NHEJ

• Gloria Terrados,

  Affiliation Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain

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• Jean-Pascal Capp,

  Affiliation Laboratoire d'Ingénierie des Sistèmes Biologiques et des Procédés. UMR INSA/CNRS, Toulouse, France

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• Yvan Canitrot,

  Affiliation CNRS-IPBS (Institute of Pharmacology and Structural Biology), Toulouse, France

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• Miguel García-Díaz,

  Affiliations Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America

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• Katarzyna Bebenek,

  Affiliation Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America

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• Tomas Kirchhoff,

  Affiliations Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain, Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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• Alberto Villanueva,

  Affiliation Laboratory of Translational Research, Institut Català d'Oncologia-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain

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• François Boudsocq,

  Affiliation CNRS-IPBS (Institute of Pharmacology and Structural Biology), Toulouse, France

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• Valérie Bergoglio,

  Affiliation CNRS-IPBS (Institute of Pharmacology and Structural Biology), Toulouse, France

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• Christophe Cazaux,

  Affiliation CNRS-IPBS (Institute of Pharmacology and Structural Biology), Toulouse, France

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• Thomas A. Kunkel,

  Affiliation Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America

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• Jean-Sébastien Hoffmann ,

  * E-mail: lblanco@cbm.uam.es (LB); jseb@ipbs.fr (JSH)

  Affiliation CNRS-IPBS (Institute of Pharmacology and Structural Biology), Toulouse, France

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• Luis Blanco

  * E-mail: lblanco@cbm.uam.es (LB); jseb@ipbs.fr (JSH)

  Affiliation Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain

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