Effects of a Flaxseed-Derived Lignan Supplement in Type 2 Diabetic Patients: A Randomized, Double-Blind, Cross-Over Trial

An Pan; Jianqin Sun; Yanqiu Chen; Xingwang Ye; Huaixing Li; Zhijie Yu; Yanfang Wang; Wenjia Gu; Xinyi Zhang; Xiafei Chen; Wendy Demark-Wahnefried; Yong Liu; Xu Lin

doi:10.1371/journal.pone.0001148

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Open Access

Peer-reviewed

Research Article

Effects of a Flaxseed-Derived Lignan Supplement in Type 2 Diabetic Patients: A Randomized, Double-Blind, Cross-Over Trial

An Pan,

Affiliation Key Laboratory of Systems Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
⨯
Jianqin Sun,

Affiliation Huadong Hospital, Fudan University, Shanghai, China
⨯
Yanqiu Chen,

Affiliation Huadong Hospital, Fudan University, Shanghai, China
⨯
Xingwang Ye,

Affiliation Key Laboratory of Systems Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
⨯
Huaixing Li,

Affiliation Key Laboratory of Systems Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
⨯
Zhijie Yu,

Affiliation Key Laboratory of Systems Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
⨯
Yanfang Wang,

Affiliation Key Laboratory of Systems Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
⨯
Wenjia Gu,

Affiliation Key Laboratory of Systems Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
⨯
Xinyi Zhang,

Affiliation Huadong Hospital, Fudan University, Shanghai, China
⨯
Xiafei Chen,

Affiliation Huadong Hospital, Fudan University, Shanghai, China
⨯
Wendy Demark-Wahnefried,

Affiliation University of Texas-MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Yong Liu,

Affiliation Key Laboratory of Systems Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
⨯
Xu Lin

*To whom correspondence should be addressed. E-mail: xlin@sibs.ac.cn

Affiliation Key Laboratory of Systems Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
⨯

Effects of a Flaxseed-Derived Lignan Supplement in Type 2 Diabetic Patients: A Randomized, Double-Blind, Cross-Over Trial

An Pan,
Jianqin Sun,
Yanqiu Chen,
Xingwang Ye,
Huaixing Li,
Zhijie Yu,
Yanfang Wang,
Wenjia Gu,
Xinyi Zhang,
Xiafei Chen

Published: November 7, 2007
https://doi.org/10.1371/journal.pone.0001148

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More results about the clinical trial

Posted by Mike1983 on 07 Nov 2007 at 11:20 GMT

We also analyzed the data according to the baseline values of HbA1C and found that lignan was more effective in improving glycemic control in the subjects with middle and top tertile of HbA1C levels. While it had no effect on HbA1C in the low tertile.

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Effects of a Flaxseed-Derived Lignan Supplement in Type 2 Diabetic Patients: A Randomized, Double-Blind, Cross-Over Trial

Effects of a Flaxseed-Derived Lignan Supplement in Type 2 Diabetic Patients: A Randomized, Double-Blind, Cross-Over Trial

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More results about the clinical trial

Posted by Mike1983 on 07 Nov 2007 at 11:20 GMT