δ-Catenin Is Genetically and Biologically Associated with Cortical Cataract and Future Alzheimer-Related Structural and Functional Brain Changes

Gyungah Jun; Juliet A. Moncaster; Carolina Koutras; Sudha Seshadri; Jacqueline Buros; Ann C. McKee; Georges Levesque; Philip A. Wolf; Peter St. George-Hyslop; Lee E. Goldstein; Lindsay A. Farrer

doi:10.1371/journal.pone.0043728

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Research Article

δ-Catenin Is Genetically and Biologically Associated with Cortical Cataract and Future Alzheimer-Related Structural and Functional Brain Changes

Gyungah Jun ,

* E-mail: gyungah@bu.edu (GJ); farrer@bu.edu (LAF)

Affiliations Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Department of Ophthalmology, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Department of Biostatistics, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America
⨯
Juliet A. Moncaster,

Affiliation Department of Psychiatry, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America
⨯
Carolina Koutras,

Affiliation Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada
⨯
Sudha Seshadri,

Affiliations Department of Neurology, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Framingham Heart Study, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America
⨯
Jacqueline Buros,

Affiliation Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America
⨯
Ann C. McKee,

Affiliations Department of Neurology, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Department of Pathology & Laboratory Medicine, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Boston University Alzheimer's Disease Center, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Geriatric Research Education Clinical Center, Bedford Veterans Administration Hospital, Bedford, Massachusetts, United States of America
⨯
Georges Levesque,

Affiliation Neurosciences Research Centre-CHUL, Université Laval, Québec, Canada
⨯
Philip A. Wolf,

Affiliations Department of Neurology, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Department of Epidemiology, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Framingham Heart Study, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America
⨯
Peter St. George-Hyslop,

Affiliations Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
⨯
Lee E. Goldstein,

Affiliations Department of Psychiatry, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Department of Neurology, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Department of Pathology & Laboratory Medicine, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Boston University Alzheimer's Disease Center, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America
⨯
Lindsay A. Farrer

* E-mail: gyungah@bu.edu (GJ); farrer@bu.edu (LAF)

Affiliations Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Department of Ophthalmology, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Department of Biostatistics, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Department of Neurology, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Department of Epidemiology, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Boston University Alzheimer's Disease Center, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America
⨯

δ-Catenin Is Genetically and Biologically Associated with Cortical Cataract and Future Alzheimer-Related Structural and Functional Brain Changes

Gyungah Jun,
Juliet A. Moncaster,
Carolina Koutras,
Sudha Seshadri,
Jacqueline Buros,
Ann C. McKee,
Georges Levesque,
Philip A. Wolf,
Peter St. George-Hyslop,
Lee E. Goldstein

Published: September 11, 2012
https://doi.org/10.1371/journal.pone.0043728

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 21 Sep 2012 at 23:35 GMT

The following articles represent some of the media coverage that has occurred for this paper:

Publication: Alzheimer's Society
Title: “Genes link dementia and cataracts, study suggests - Alzheimer's Society”
http://www.alzheimers.org...

Publication: Medical Daily
Title: “A Simple Eye Test May Be Able to Detect Alzheimer's Disease : Conditions : Medical Daily”
http://www.medicaldaily.c...

Publication: Express.co.uk
Title: “Eye test clue to Alzheimer's | UK News | Express.co.uk - Home of the Daily and Sunday Express”
http://www.express.co.uk/...

Publication: Daily Mail
Title: “Eye test may be early indicator of Alzheimer's, say scientists after linking brain disease to cataracts | Mail Online”
http://www.dailymail.co.u...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS ONE Staff

RE: Media Coverage of This Article

gyungah replied to PLOS_ONE_Group on 24 Sep 2012 at 17:53 GMT

Additional media coverage:

Science Daily:
http://www.sciencedaily.c...

Monreal Gazette:
http://www.montrealgazett...

Daily Free Press:
http://dailyfreepress.com...

Truth Dive:
http://truthdive.com/2012...

Med India:
http://www.medindia.net/h...

Simply Health:
https://www.simplyhealth....

Topix:
http://www.topix.com/coll...
d-link-in-dna-connecting-cataracts-to-alzheimers

Topix:
http://www.topix.com/coll...

Sciendce Codex:
http://www.sciencecodex.c...

Bio Space:
http://www.biospace.com/n...

Regator:
http://regator.com/p/2574...

Medical Xpress:
http://medicalxpress.com/...

Nutrition Review:
http://www.nutritionrevie...

BioPortfolio:
http://www.bioportfolio.c...

Feed My Science:
http://feedmyscience.com/...

No competing interests declared.

RE: RE: Media Coverage of This Article

PLOS_ONE_Group replied to gyungah on 10 Nov 2012 at 00:50 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: EveryONE PLOS ONE Community Blog
Title: “Great Genetics: PLOS ONE at ASHG | EveryONE”
http://blogs.plos.org/eve...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS ONE Staff

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δ-Catenin Is Genetically and Biologically Associated with Cortical Cataract and Future Alzheimer-Related Structural and Functional Brain Changes

δ-Catenin Is Genetically and Biologically Associated with Cortical Cataract and Future Alzheimer-Related Structural and Functional Brain Changes

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 21 Sep 2012 at 23:35 GMT

RE: Media Coverage of This Article

gyungah replied to PLOS_ONE_Group on 24 Sep 2012 at 17:53 GMT

RE: RE: Media Coverage of This Article

PLOS_ONE_Group replied to gyungah on 10 Nov 2012 at 00:50 GMT