Appetite Enhancement and Weight Gain by Peripheral Administration of TrkB Agonists in Non-Human Primates

John C. Lin; David Tsao; Paul Barras; Raul A. Bastarrachea; Bob Boyd; Joyce Chou; Rodnie Rosete; Hua Long; Alison Forgie; Yasmina Abdiche; Jeanette Dilley; Jennifer Stratton; Carlos Garcia; David L. Sloane; Anthony G. Comuzzie; Arnon Rosenthal

doi:10.1371/journal.pone.0001900

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Open Access

Peer-reviewed

Research Article

Appetite Enhancement and Weight Gain by Peripheral Administration of TrkB Agonists in Non-Human Primates

John C. Lin ,

* E-mail: john.lin@rinat.pfizer.com

Affiliation Rinat, Pfizer Inc., South San Francisco, California, United States of America
⨯
David Tsao,

Affiliation Rinat, Pfizer Inc., South San Francisco, California, United States of America
⨯
Paul Barras,

Affiliation Alpha Genesis, Inc., Yemassee, South Carolina, United States of America
⨯
Raul A. Bastarrachea,

Affiliation Southwest Foundation for Biomedical Research, San Antonio, Texas, United States of America
⨯
Bob Boyd,

Affiliation Northern Biomedical Research, Muskegon, Michigan, United States of America
⨯
Joyce Chou,

Affiliation Rinat, Pfizer Inc., South San Francisco, California, United States of America
⨯
Rodnie Rosete,

Affiliation Rinat, Pfizer Inc., South San Francisco, California, United States of America
⨯
Hua Long,

Affiliation Rinat, Pfizer Inc., South San Francisco, California, United States of America
⨯
Alison Forgie,

Affiliation Rinat, Pfizer Inc., South San Francisco, California, United States of America
⨯
Yasmina Abdiche,

Affiliation Rinat, Pfizer Inc., South San Francisco, California, United States of America
⨯
Jeanette Dilley,

Affiliation Rinat, Pfizer Inc., South San Francisco, California, United States of America
⨯
Jennifer Stratton,

Affiliation Rinat, Pfizer Inc., South San Francisco, California, United States of America
⨯
Carlos Garcia,

Affiliation Rinat, Pfizer Inc., South San Francisco, California, United States of America
⨯
David L. Sloane,

Affiliation Rinat, Pfizer Inc., South San Francisco, California, United States of America
⨯
Anthony G. Comuzzie,

Affiliation Southwest Foundation for Biomedical Research, San Antonio, Texas, United States of America
⨯
[ ... ],
Arnon Rosenthal

Affiliation Rinat, Pfizer Inc., South San Francisco, California, United States of America
⨯
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Appetite Enhancement and Weight Gain by Peripheral Administration of TrkB Agonists in Non-Human Primates

John C. Lin,
David Tsao,
Paul Barras,
Raul A. Bastarrachea,
Bob Boyd,
Joyce Chou,
Rodnie Rosete,
Hua Long,
Alison Forgie,
Yasmina Abdiche

Published: April 2, 2008
https://doi.org/10.1371/journal.pone.0001900

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Referee Comments: Referee 2

Posted by PLOS_ONE_Group on 07 Apr 2008 at 23:19 GMT

Referee 2's Comments:

The authors have carefully considered and responded to the referees comments and the paper is much improved.

**********
N.B. These are the comments made by the referee when reviewing an earlier version of this paper. Prior to publication the manuscript has been revised in light of these comments and to address other editorial requirements.

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Appetite Enhancement and Weight Gain by Peripheral Administration of TrkB Agonists in Non-Human Primates

Appetite Enhancement and Weight Gain by Peripheral Administration of TrkB Agonists in Non-Human Primates

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Referee Comments: Referee 2

Posted by PLOS_ONE_Group on 07 Apr 2008 at 23:19 GMT