Regulation of Hemolysin Expression and Virulence of Staphylococcus aureus by a Serine/Threonine Kinase and Phosphatase

Kellie Burnside; Annalisa Lembo; Melissa de los Reyes; Anton Iliuk; Nguyen-Thao BinhTran; James E. Connelly; Wan-Jung Lin; Byron Z. Schmidt; Anthony R. Richardson; Ferric C. Fang; Weiguo Andy Tao; Lakshmi Rajagopal

doi:10.1371/journal.pone.0011071

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Peer-reviewed

Research Article

Regulation of Hemolysin Expression and Virulence of Staphylococcus aureus by a Serine/Threonine Kinase and Phosphatase

Kellie Burnside,

Affiliation Department of Pediatric Infectious Diseases, University of Washington and Seattle Children's Hospital Research Institute, Seattle, Washington, United States of America
⨯
Annalisa Lembo,

Affiliation Department of Pediatric Infectious Diseases, University of Washington and Seattle Children's Hospital Research Institute, Seattle, Washington, United States of America
⨯
Melissa de los Reyes,

Affiliation Department of Pediatric Infectious Diseases, University of Washington and Seattle Children's Hospital Research Institute, Seattle, Washington, United States of America
⨯
Anton Iliuk,

Affiliation Department of Biochemistry, Purdue University, West Lafayette, Indiana, United States of America
⨯
Nguyen-Thao BinhTran,

Affiliation Department of Pediatric Infectious Diseases, University of Washington and Seattle Children's Hospital Research Institute, Seattle, Washington, United States of America
⨯
James E. Connelly,

Current address: James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, United States of America

Affiliation Department of Pediatric Infectious Diseases, University of Washington and Seattle Children's Hospital Research Institute, Seattle, Washington, United States of America
⨯
Wan-Jung Lin,

Current address: Michael G. Foster School of Business, University of Washington, Seattle, Washington, United States of America

Affiliation Department of Pediatric Infectious Diseases, University of Washington and Seattle Children's Hospital Research Institute, Seattle, Washington, United States of America
⨯
Byron Z. Schmidt,

Affiliation Department of Pediatric Infectious Diseases, University of Washington and Seattle Children's Hospital Research Institute, Seattle, Washington, United States of America
⨯
Anthony R. Richardson,

Current address: Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Affiliation Departments of Laboratory Medicine and Microbiology, University of Washington, Seattle, Washington, United States of America
⨯
Ferric C. Fang,

Affiliation Departments of Laboratory Medicine and Microbiology, University of Washington, Seattle, Washington, United States of America
⨯
Weiguo Andy Tao,

Affiliation Department of Biochemistry, Purdue University, West Lafayette, Indiana, United States of America
⨯
Lakshmi Rajagopal

* E-mail: lakshmi.rajagopal@seattlechildrens.org

Affiliation Department of Pediatric Infectious Diseases, University of Washington and Seattle Children's Hospital Research Institute, Seattle, Washington, United States of America
⨯

Regulation of Hemolysin Expression and Virulence of Staphylococcus aureus by a Serine/Threonine Kinase and Phosphatase

Kellie Burnside,
Annalisa Lembo,
Melissa de los Reyes,
Anton Iliuk,
Nguyen-Thao BinhTran,
James E. Connelly,
Wan-Jung Lin,
Byron Z. Schmidt,
Anthony R. Richardson,
Ferric C. Fang

Published: June 11, 2010
https://doi.org/10.1371/journal.pone.0011071

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Gene nomenclature

Posted by gomelsky on 06 Jul 2010 at 06:53 GMT

Note that SA0014, designated gdpP (Holland et al., 2008), is not a putative diguanylate cyclase, but a putative diadenylate phosphodiesterase (Rao et al., 2010).

Holland, L.M., S.T. O’Donnell, D.A. Ryjenkov, L. Gomelsky, S.R. Slater, P.D. Fey, M. Gomelsky, and J.P. O’Gara. 2008. A staphylococcal GGDEF domain protein regulates biofilm formation independently of c-di-GMP. J Bacteriol 190:5178–5189.

Rao, F., R.Y. See, D. Zhang, D.C. Toh, Q. Ji, and Z.X. Liang. 2010. YybT is a signaling protein that contains a cyclic dinucleotide phosphodiesterase domain and a GGDEF domain with ATPase activity. J Biol Chem 285:473-482.

No competing interests declared.

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Regulation of Hemolysin Expression and Virulence of Staphylococcus aureus by a Serine/Threonine Kinase and Phosphatase

Regulation of Hemolysin Expression and Virulence of Staphylococcus aureus by a Serine/Threonine Kinase and Phosphatase

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Gene nomenclature

Posted by gomelsky on 06 Jul 2010 at 06:53 GMT