Metformin Represses Self-Renewal of the Human Breast Carcinoma Stem Cells via Inhibition of Estrogen Receptor-Mediated OCT4 Expression

Ji-Won Jung; Sang-Bum Park; Soo-Jin Lee; Min-Soo Seo; James E. Trosko; Kyung-Sun Kang

doi:10.1371/journal.pone.0028068

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Research Article

Metformin Represses Self-Renewal of the Human Breast Carcinoma Stem Cells via Inhibition of Estrogen Receptor-Mediated OCT4 Expression

Ji-Won Jung ,

Contributed equally to this work with: Ji-Won Jung, Sang-Bum Park

Current address: Division of Intractable Diseases, Center for Biomedical Science, Korea National Institute of Health, Chungbuk, Korea

Affiliation Department of Veterinary Public Health, College of Veterinary Medicine, Adult Stem Cell Research Center, Seoul National University, Seoul, Republic of Korea
⨯
Sang-Bum Park ,

Contributed equally to this work with: Ji-Won Jung, Sang-Bum Park

Affiliation Department of Veterinary Public Health, College of Veterinary Medicine, Adult Stem Cell Research Center, Seoul National University, Seoul, Republic of Korea
⨯
Soo-Jin Lee,

Affiliation Department of Veterinary Public Health, College of Veterinary Medicine, Adult Stem Cell Research Center, Seoul National University, Seoul, Republic of Korea
⨯
Min-Soo Seo,

Affiliation Department of Veterinary Public Health, College of Veterinary Medicine, Adult Stem Cell Research Center, Seoul National University, Seoul, Republic of Korea
⨯
James E. Trosko,

Affiliations Department of Veterinary Public Health, College of Veterinary Medicine, Adult Stem Cell Research Center, Seoul National University, Seoul, Republic of Korea, Department of Pediatrics and Human Development, College of Human Medicine, Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan, United States of America
⨯
Kyung-Sun Kang

* E-mail: kangpub@snu.ac.kr

Affiliation Department of Veterinary Public Health, College of Veterinary Medicine, Adult Stem Cell Research Center, Seoul National University, Seoul, Republic of Korea
⨯

Metformin Represses Self-Renewal of the Human Breast Carcinoma Stem Cells via Inhibition of Estrogen Receptor-Mediated OCT4 Expression

Ji-Won Jung,
Sang-Bum Park,
Soo-Jin Lee,
Min-Soo Seo,
James E. Trosko,
Kyung-Sun Kang

Published: November 23, 2011
https://doi.org/10.1371/journal.pone.0028068

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 02 Dec 2011 at 18:44 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: Diabetes.co.uk
Title: “Diabetes drug metformin could help lower breast cancer risk”
http://www.diabetes.co.uk...

Publication: Michigan State University News
Title: “Diabetes drug shows promise in reducing risk of cancer | MSU News | Michigan State University”
http://news.msu.edu/story...

Publication: Heal Blog
Title: “Cancer-Risk Can Be Prevented by Diabetes Drug-Metformin”
http://www.healblog.net/h...

Publication: Emax Health
Title: “Diabetes Drug Metformin May Have Anticancer Abilities”
http://www.emaxhealth.com...

Publication: Indo Asian News Service
Title: “Diabetes drug reduces cancer risk”
http://www.khaleejtimes.c...

Publication: Barchester Healthcare News
Title: “Diabetes drug 'could cut breast cancer risk'”
http://www.barchester.com...

Publication: Michigan State University News
Title: “Diabetes drug shows promise in reducing risk of cancer”
http://news.msu.edu/story...

Publication: Mlive.com
Title: “MSU research: Diabetes drug shows potential in reducing cancer risk”
http://www.mlive.com/lans...

Publication: All Headline News
Title: “Diabetes drug shown to reduce cancer risk”
http://www.allheadlinenew...

Publication: Private Healthcare UK
Title: “Breast cancer 'could be treated with diabetic drug'”
http://www.privatehealth....

Publication: Digital Journal
Title: “Inexpensive diabetes drug might help fight cancer”
http://www.digitaljournal...

Publication: UPI
Title: “Drug may help prevent breast cancer”
http://www.upi.com/Health...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLoS ONE Staff

RE: Media Coverage of This Article

PLOS_ONE_Group replied to PLOS_ONE_Group on 09 Dec 2011 at 21:27 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: Oncology Nurse Advisor
Title: “Diabetes drug helps prevent growth of breast cancer cells - ONA”
http://www.oncologynursea...

Publication: HemOncToday
Title: “Diabetes drug reduced size, number of breast cancer stem cells | HemOncToday: Hematology & Oncology News”
http://www.hemonctoday.co...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLoS ONE Staff

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Metformin Represses Self-Renewal of the Human Breast Carcinoma Stem Cells via Inhibition of Estrogen Receptor-Mediated OCT4 Expression

Metformin Represses Self-Renewal of the Human Breast Carcinoma Stem Cells via Inhibition of Estrogen Receptor-Mediated OCT4 Expression

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 02 Dec 2011 at 18:44 GMT

RE: Media Coverage of This Article

PLOS_ONE_Group replied to PLOS_ONE_Group on 09 Dec 2011 at 21:27 GMT