Krüppel-Like Factor 4, a Tumor Suppressor in Hepatocellular Carcinoma Cells Reverts Epithelial Mesenchymal Transition by Suppressing Slug Expression

Ze-Shiang Lin; Hsiao-Chien Chu; Yi-Chen Yen; Brian C. Lewis; Ya-Wen Chen

doi:10.1371/journal.pone.0043593

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Research Article

Krüppel-Like Factor 4, a Tumor Suppressor in Hepatocellular Carcinoma Cells Reverts Epithelial Mesenchymal Transition by Suppressing Slug Expression

Ze-Shiang Lin ,

Contributed equally to this work with: Ze-Shiang Lin, Hsiao-Chien Chu

Affiliation National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan
⨯
Hsiao-Chien Chu ,

Contributed equally to this work with: Ze-Shiang Lin, Hsiao-Chien Chu

Affiliation National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan
⨯
Yi-Chen Yen,

Affiliation National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan
⨯
Brian C. Lewis,

Affiliations Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Ya-Wen Chen

* E-mail: ywc@nhri.org.tw

Affiliation National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan
⨯

Krüppel-Like Factor 4, a Tumor Suppressor in Hepatocellular Carcinoma Cells Reverts Epithelial Mesenchymal Transition by Suppressing Slug Expression

Ze-Shiang Lin,
Hsiao-Chien Chu,
Yi-Chen Yen,
Brian C. Lewis,
Ya-Wen Chen

Published: August 24, 2012
https://doi.org/10.1371/journal.pone.0043593

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Erratum

Posted by ywcnhri on 09 Apr 2013 at 02:03 GMT

In tail vein injection experiments, we observed that ectopic Klf4 expression led to reduced colony formation in the lungs under macroscopic and microscopic views (Figure 2C) and a dramatic decrease in total lung weight (0.3883±0.05275 g vs. 0.6983±0.1157 g for controls, n= 6) (Figure 2D).

No competing interests declared.

Erratum II

ywcnhri replied to ywcnhri on 09 Mar 2016 at 08:30 GMT

In Figure 6F, the r should be -0.36.

No competing interests declared.

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Lung and intrathoracic tumors
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Hepatocellular carcinoma
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Krüppel-Like Factor 4, a Tumor Suppressor in Hepatocellular Carcinoma Cells Reverts Epithelial Mesenchymal Transition by Suppressing Slug Expression

Krüppel-Like Factor 4, a Tumor Suppressor in Hepatocellular Carcinoma Cells Reverts Epithelial Mesenchymal Transition by Suppressing Slug Expression

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Erratum

Posted by ywcnhri on 09 Apr 2013 at 02:03 GMT

Erratum II

ywcnhri replied to ywcnhri on 09 Mar 2016 at 08:30 GMT