Long-Term Stimulant Treatment Affects Brain Dopamine Transporter Level in Patients with Attention Deficit Hyperactive Disorder

Gene-Jack Wang; Nora D. Volkow; Timothy Wigal; Scott H. Kollins; Jeffrey H. Newcorn; Frank Telang; Jean Logan; Millard Jayne; Christopher T. Wong; Hao Han; Joanna S. Fowler; Wei Zhu; James M. Swanson

doi:10.1371/journal.pone.0063023

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Peer-reviewed

Research Article

Long-Term Stimulant Treatment Affects Brain Dopamine Transporter Level in Patients with Attention Deficit Hyperactive Disorder

Gene-Jack Wang ,

* E-mail: gjwang@bnl.gov

Affiliations Department of Radiology, Stony Brook University, Stony Brook, New York, United States of America, Bioscience Department, Brookhaven National Laboratory, Upton, New York, United States of America, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America
⨯
Nora D. Volkow,

Affiliations National Institute on Drug Abuse, Bethesda, Maryland, United States of America, Neuroimaging Lab, National Institute on Alcohol Abuse and Alcoholism Intramural Research Program, Upton, New York, United States of America
⨯
Timothy Wigal,

Affiliation Department of Pediatrics, University of California Irvine, Irvine, California, United States of America
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Scott H. Kollins,

Affiliation Department of Psychiatry, Duke University, Durham, North Carolina, United States of America
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Jeffrey H. Newcorn,

Affiliation Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America
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Frank Telang,

Affiliation Neuroimaging Lab, National Institute on Alcohol Abuse and Alcoholism Intramural Research Program, Upton, New York, United States of America
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Jean Logan,

Affiliation Bioscience Department, Brookhaven National Laboratory, Upton, New York, United States of America
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Millard Jayne,

Affiliation Neuroimaging Lab, National Institute on Alcohol Abuse and Alcoholism Intramural Research Program, Upton, New York, United States of America
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Christopher T. Wong,

Affiliation Neuroimaging Lab, National Institute on Alcohol Abuse and Alcoholism Intramural Research Program, Upton, New York, United States of America
⨯
Hao Han,

Affiliation Department of Mathematics and Applied Sciences, Stony Brook University, Stony Brook, New York, United States of America
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Joanna S. Fowler,

Affiliations Bioscience Department, Brookhaven National Laboratory, Upton, New York, United States of America, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America
⨯
Wei Zhu,

Affiliation Department of Mathematics and Applied Sciences, Stony Brook University, Stony Brook, New York, United States of America
⨯
James M. Swanson

Affiliation Department of Pediatrics, University of California Irvine, Irvine, California, United States of America
⨯

Long-Term Stimulant Treatment Affects Brain Dopamine Transporter Level in Patients with Attention Deficit Hyperactive Disorder

Gene-Jack Wang,
Nora D. Volkow,
Timothy Wigal,
Scott H. Kollins,
Jeffrey H. Newcorn,
Frank Telang,
Jean Logan,
Millard Jayne,
Christopher T. Wong,
Hao Han

Published: May 15, 2013
https://doi.org/10.1371/journal.pone.0063023

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Earlier investigation on this topic

Posted by khkrause on 17 May 2013 at 08:24 GMT

This is not the first study showing an increase of DAT in patients with ADHD after long term therapy with methylphenidate. In 2005 Feron et al. found an increase of 17% of DAT availability, measured by FP-CIT-SPECT, in male boys with ADHD after long term MPH-therapy (Feron FJ, Hendriksen JG, van Kroonenburgh MJ, Blom-Coenjaerts C, Kessels AG, Jolles J, Weber WE, Vles JS. Dopamine transporter in attention-deficit hyperactivity disorder normalizes after cessation of methylphenidate. Pediatr Neurol. 2005 Sep;33(3):179-83.), as we described already in our book „ADHS im Erwachsenenalter“ (3rd edition, Stuttgart, New York: Schattauer 2009).
Johanna and Klaus-Henning Krause

No competing interests declared.

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Long-Term Stimulant Treatment Affects Brain Dopamine Transporter Level in Patients with Attention Deficit Hyperactive Disorder

Long-Term Stimulant Treatment Affects Brain Dopamine Transporter Level in Patients with Attention Deficit Hyperactive Disorder

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Earlier investigation on this topic

Posted by khkrause on 17 May 2013 at 08:24 GMT