Short-Term Calorie Restriction in Male Mice Feminizes Gene Expression and Alters Key Regulators of Conserved Aging Regulatory Pathways

Preston Wayne Estep III; Jason B. Warner; Martha L. Bulyk

doi:10.1371/journal.pone.0005242

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Peer-reviewed

Research Article

Short-Term Calorie Restriction in Male Mice Feminizes Gene Expression and Alters Key Regulators of Conserved Aging Regulatory Pathways

Preston Wayne Estep III ,

* E-mail: pestep@post.harvard.edu

Affiliation Longenity, Inc., Lincoln, Massachusetts, United States of America
⨯
Jason B. Warner,

Affiliation Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
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Martha L. Bulyk

Affiliations Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Harvard-MIT Division of Health Sciences and Technology (HST), Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Short-Term Calorie Restriction in Male Mice Feminizes Gene Expression and Alters Key Regulators of Conserved Aging Regulatory Pathways

Preston Wayne Estep III,
Jason B. Warner,
Martha L. Bulyk

Published: April 16, 2009
https://doi.org/10.1371/journal.pone.0005242

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Publisher's Note: "upregulated" and "downregulated" switched in one place

Posted by pwestep on 21 Apr 2009 at 21:16 GMT

They also found that genes involved in lipid and steroid metabolism were upregulated but in contrast to our results they found a subset of lipid metabolism genes downregulated
http://plosone.org/article/info:doi/10.1371/journal.pone.0005242#article1.body1.sec3.p9

The statement in the Discussion section (page 8 on PDF) that reads
"They also found that genes involved in lipid and steroid metabolism were upregulated but in contrast to our results they found a subset of lipid metabolism genes downregulated ..."

should instead read
"They also found that genes involved in lipid and steroid metabolism were downregulated but in contrast to our results they found a subset of lipid metabolism genes upregulated ..."

No competing interests declared.

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Regulator genes
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Short-Term Calorie Restriction in Male Mice Feminizes Gene Expression and Alters Key Regulators of Conserved Aging Regulatory Pathways

Short-Term Calorie Restriction in Male Mice Feminizes Gene Expression and Alters Key Regulators of Conserved Aging Regulatory Pathways

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Publisher's Note: "upregulated" and "downregulated" switched in one place

Posted by pwestep on 21 Apr 2009 at 21:16 GMT