A Melanoma Brain Metastasis with a Donor-Patient Hybrid Genome following Bone Marrow Transplantation: First Evidence for Fusion in Human Cancer

Rossitza Lazova; Greggory S. LaBerge; Eric Duvall; Nicole Spoelstra; Vincent Klump; Mario Sznol; Dennis Cooper; Richard A. Spritz; Joseph T. Chang; John M. Pawelek

doi:10.1371/journal.pone.0066731

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Peer-reviewed

Research Article

A Melanoma Brain Metastasis with a Donor-Patient Hybrid Genome following Bone Marrow Transplantation: First Evidence for Fusion in Human Cancer

Rossitza Lazova ,

Contributed equally to this work with: Rossitza Lazova, Greggory S. LaBerge

Affiliations Deptartment of Dermatology, Yale School of Medicine, New Haven, Connecticut, United States of America, The Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut, United States of America
⨯
Greggory S. LaBerge ,

Contributed equally to this work with: Rossitza Lazova, Greggory S. LaBerge

Affiliations Human Medical Genetics and Genomics Program, University of Colorado School of Medicine, Aurora, Colorado, United States of America, Denver Police Department Crime Lab, Denver, Colorado, United States of America
⨯
Eric Duvall,

Affiliation Denver Police Department Crime Lab, Denver, Colorado, United States of America
⨯
Nicole Spoelstra,

Affiliation Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States of America
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Vincent Klump,

Affiliation Deptartment of Dermatology, Yale School of Medicine, New Haven, Connecticut, United States of America
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Mario Sznol,

Affiliations The Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut, United States of America, Medical Oncology, Yale School of Medicine, New Haven, Connecticut, United States of America
⨯
Dennis Cooper,

Affiliations The Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut, United States of America, Medical Oncology, Yale School of Medicine, New Haven, Connecticut, United States of America
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Richard A. Spritz,

Affiliation Human Medical Genetics and Genomics Program, University of Colorado School of Medicine, Aurora, Colorado, United States of America
⨯
Joseph T. Chang,

Affiliation Statistics Department, Yale University, New Haven, Connecticut, United States of America
⨯
John M. Pawelek

* E-mail: john.pawelek@yale.edu

Affiliations Deptartment of Dermatology, Yale School of Medicine, New Haven, Connecticut, United States of America, The Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut, United States of America
⨯

A Melanoma Brain Metastasis with a Donor-Patient Hybrid Genome following Bone Marrow Transplantation: First Evidence for Fusion in Human Cancer

Rossitza Lazova,
Greggory S. LaBerge,
Eric Duvall,
Nicole Spoelstra,
Vincent Klump,
Mario Sznol,
Dennis Cooper,
Richard A. Spritz,
Joseph T. Chang,
John M. Pawelek

Published: June 26, 2013
https://doi.org/10.1371/journal.pone.0066731

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Media Coverage of this Article

Posted by PLOS_ONE_Group on 22 Jul 2013 at 20:47 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: Oncology Nurse Advisor
Title: “Fusion of cancer cells to leukocytes may explain distant metastasis - ONA”
http://www.oncologynursea...

Publication: News Medical
Title: “Discovery of hybrid cells in human melanoma”
http://www.news-medical.n...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS ONE Staff

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A Melanoma Brain Metastasis with a Donor-Patient Hybrid Genome following Bone Marrow Transplantation: First Evidence for Fusion in Human Cancer

A Melanoma Brain Metastasis with a Donor-Patient Hybrid Genome following Bone Marrow Transplantation: First Evidence for Fusion in Human Cancer

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Media Coverage of this Article

Posted by PLOS_ONE_Group on 22 Jul 2013 at 20:47 GMT