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closeanswer to Dr Falconar's comment
Posted by parisp on 10 Apr 2012 at 20:40 GMT
I thank Dr Falconar for kind commentary on our work. Indeed, this was a long and difficult study to conceive and carry-out. Each critical step from study design to manual analysis of gene signature was carefully prepared and carried out to make this work as rigourous and informative as possible.
Finally, while hybridization of gene expression microarrays producing millions of raw data now take a few days, several weeks or months are required to move from raw data to understanding of connexions existing between gene signatures identified and disease process studied. This likely explains why our study provided a global and larger overview of biological processes altered at the time of DSS decompensation compared to studies published during the same year by other dengue teams who mainly focussed on over-expression of neutrophil-related genes in DSS patients.
The true powerfulness of such approaches is, to my opinion, their ability to decipher the complexity of biological mechanisms altered in the course of a disease process and to highlight the similarities between distinct pathologies or syndromes. This, indeed, may open new ways for treatments of a given disease using therapies implemented for other pathologies.