Characterization of a Natural Mutator Variant of Human DNA Polymerase λ which Promotes Chromosomal Instability by Compromising NHEJ

Gloria Terrados; Jean-Pascal Capp; Yvan Canitrot; Miguel García-Díaz; Katarzyna Bebenek; Tomas Kirchhoff; Alberto Villanueva; François Boudsocq; Valérie Bergoglio; Christophe Cazaux; Thomas A. Kunkel; Jean-Sébastien Hoffmann; Luis Blanco

doi:10.1371/journal.pone.0007290

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Open Access

Peer-reviewed

Research Article

Characterization of a Natural Mutator Variant of Human DNA Polymerase λ which Promotes Chromosomal Instability by Compromising NHEJ

Gloria Terrados,

Affiliation Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain
⨯
Jean-Pascal Capp,

Affiliation Laboratoire d'Ingénierie des Sistèmes Biologiques et des Procédés. UMR INSA/CNRS, Toulouse, France
⨯
Yvan Canitrot,

Affiliation CNRS-IPBS (Institute of Pharmacology and Structural Biology), Toulouse, France
⨯
Miguel García-Díaz,

Affiliations Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America
⨯
Katarzyna Bebenek,

Affiliation Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America
⨯
Tomas Kirchhoff,

Affiliations Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain, Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
⨯
Alberto Villanueva,

Affiliation Laboratory of Translational Research, Institut Català d'Oncologia-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain
⨯
François Boudsocq,

Affiliation CNRS-IPBS (Institute of Pharmacology and Structural Biology), Toulouse, France
⨯
Valérie Bergoglio,

Affiliation CNRS-IPBS (Institute of Pharmacology and Structural Biology), Toulouse, France
⨯
Christophe Cazaux,

Affiliation CNRS-IPBS (Institute of Pharmacology and Structural Biology), Toulouse, France
⨯
Thomas A. Kunkel,

Affiliation Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America
⨯
Jean-Sébastien Hoffmann ,

* E-mail: lblanco@cbm.uam.es (LB); jseb@ipbs.fr (JSH)

Affiliation CNRS-IPBS (Institute of Pharmacology and Structural Biology), Toulouse, France
⨯
Luis Blanco

* E-mail: lblanco@cbm.uam.es (LB); jseb@ipbs.fr (JSH)

Affiliation Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain
⨯

Characterization of a Natural Mutator Variant of Human DNA Polymerase λ which Promotes Chromosomal Instability by Compromising NHEJ

Gloria Terrados,
Jean-Pascal Capp,
Yvan Canitrot,
Miguel García-Díaz,
Katarzyna Bebenek,
Tomas Kirchhoff,
Alberto Villanueva,
François Boudsocq,
Valérie Bergoglio,
Christophe Cazaux

Published: October 6, 2009
https://doi.org/10.1371/journal.pone.0007290

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Publisher's Note: ordinates part D

Posted by luisblanco on 08 Oct 2009 at 10:45 GMT

.
http://plosone.org/article/info:doi/10.1371/journal.pone.0007290#pone-0007290-g004

In part D, ordinates should be:

Frequency (%)

No competing interests declared.

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Non-homologous end joining
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DNA repair
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DNA polymerase
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Cloning
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Transfection
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Chromosome structure and function
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Characterization of a Natural Mutator Variant of Human DNA Polymerase λ which Promotes Chromosomal Instability by Compromising NHEJ

Characterization of a Natural Mutator Variant of Human DNA Polymerase λ which Promotes Chromosomal Instability by Compromising NHEJ

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Publisher's Note: ordinates part D

Posted by luisblanco on 08 Oct 2009 at 10:45 GMT