HIV-1 Enhancing Effect of Prostatic Acid Phosphatase Peptides Is Reduced in Human Seminal Plasma

Julie A. Martellini; Amy L. Cole; Pavel Svoboda; Olga Stuchlik; Li-Mei Chen; Karl X. Chai; Bhushan K. Gangrade; Ole E. Sørensen; Jan Pohl; Alexander M. Cole

doi:10.1371/journal.pone.0016285

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Open Access

Peer-reviewed

Research Article

HIV-1 Enhancing Effect of Prostatic Acid Phosphatase Peptides Is Reduced in Human Seminal Plasma

Julie A. Martellini,

Affiliation Department of Molecular Biology & Microbiology, Biomolecular Science Center, Burnett School of Biomedical Sciences at the University of Central Florida College of Medicine, Orlando, Florida, United States of America
⨯
Amy L. Cole,

Affiliation Department of Molecular Biology & Microbiology, Biomolecular Science Center, Burnett School of Biomedical Sciences at the University of Central Florida College of Medicine, Orlando, Florida, United States of America
⨯
Pavel Svoboda,

Affiliations Microchemical and Proteomics Facility, Emory University, Atlanta, Georgia, United States of America, Biotechnology Core Facility Branch, Division of Safety Research, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
⨯
Olga Stuchlik,

Affiliation Biotechnology Core Facility Branch, Division of Safety Research, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
⨯
Li-Mei Chen,

Affiliation Department of Molecular Biology & Microbiology, Biomolecular Science Center, Burnett School of Biomedical Sciences at the University of Central Florida College of Medicine, Orlando, Florida, United States of America
⨯
Karl X. Chai,

Affiliation Department of Molecular Biology & Microbiology, Biomolecular Science Center, Burnett School of Biomedical Sciences at the University of Central Florida College of Medicine, Orlando, Florida, United States of America
⨯
Bhushan K. Gangrade,

Affiliation Center for Reproductive Medicine, Orlando, Florida, United States of America
⨯
Ole E. Sørensen,

Affiliation Division of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden
⨯
Jan Pohl,

Affiliations Microchemical and Proteomics Facility, Emory University, Atlanta, Georgia, United States of America, Biotechnology Core Facility Branch, Division of Safety Research, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
⨯
Alexander M. Cole

* E-mail: acole@mail.ucf.edu

Affiliation Department of Molecular Biology & Microbiology, Biomolecular Science Center, Burnett School of Biomedical Sciences at the University of Central Florida College of Medicine, Orlando, Florida, United States of America
⨯

HIV-1 Enhancing Effect of Prostatic Acid Phosphatase Peptides Is Reduced in Human Seminal Plasma

Julie A. Martellini,
Amy L. Cole,
Pavel Svoboda,
Olga Stuchlik,
Li-Mei Chen,
Karl X. Chai,
Bhushan K. Gangrade,
Ole E. Sørensen,
Jan Pohl,
Alexander M. Cole

Published: January 20, 2011
https://doi.org/10.1371/journal.pone.0016285

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Citation

Posted by sheldonz on 13 Apr 2013 at 00:30 GMT

Peripheral Blood Mononuclear Cells (PBMCs) were obtained from healthy donors by AllCells, LLC (Emeryville, CA, USA), http://www.allcells.com

No competing interests declared.

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HIV-1
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Proteases
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Semen
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Amyloid proteins
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MTT assay
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Antiviral therapy
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Electrophoretic staining
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Cytotoxicity assay
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HIV-1 Enhancing Effect of Prostatic Acid Phosphatase Peptides Is Reduced in Human Seminal Plasma

HIV-1 Enhancing Effect of Prostatic Acid Phosphatase Peptides Is Reduced in Human Seminal Plasma

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Citation

Posted by sheldonz on 13 Apr 2013 at 00:30 GMT