Gene Expression Signature of Cigarette Smoking and Its Role in Lung Adenocarcinoma Development and Survival

Maria Teresa Landi; Tatiana Dracheva; Melissa Rotunno; Jonine D. Figueroa; Huaitian Liu; Abhijit Dasgupta; Felecia E. Mann; Junya Fukuoka; Megan Hames; Andrew W. Bergen; Sharon E. Murphy; Ping Yang; Angela C. Pesatori; Dario Consonni; Pier Alberto Bertazzi; Sholom Wacholder; Joanna H. Shih; Neil E. Caporaso; Jin Jen

doi:10.1371/journal.pone.0001651

Loading metrics

Open Access

Peer-reviewed

Research Article

Gene Expression Signature of Cigarette Smoking and Its Role in Lung Adenocarcinoma Development and Survival

Maria Teresa Landi ,

*E-mail: landim@mail.nih.gov

Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, United States of America
⨯
Tatiana Dracheva,

Affiliation Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, United States of America
⨯
Melissa Rotunno,

Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, United States of America
⨯
Jonine D. Figueroa,

Affiliations Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, United States of America, Cancer Prevention Fellowship, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, United States of America
⨯
Huaitian Liu,

Affiliation Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, United States of America
⨯
Abhijit Dasgupta,

Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, United States of America
⨯
Felecia E. Mann,

Affiliation Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, United States of America
⨯
Junya Fukuoka,

Affiliation Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, United States of America
⨯
Megan Hames,

Affiliation Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, United States of America
⨯
Andrew W. Bergen,

Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, United States of America
⨯
Sharon E. Murphy,

Affiliation Biochemistry, Molecular Biology and Biophysics, University of Minnesota Cancer Center, Minneapolis, Minnesota, United States of America
⨯
Ping Yang,

Affiliation Department of Health Science, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Angela C. Pesatori,

Affiliation Foundation OM Policlinic, University of Milan, Milan, Italy
⨯
Dario Consonni,

Affiliation Foundation OM Policlinic, University of Milan, Milan, Italy
⨯
Pier Alberto Bertazzi,

Affiliation Foundation OM Policlinic, University of Milan, Milan, Italy
⨯
Sholom Wacholder,

Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, United States of America
⨯
Joanna H. Shih,

Affiliation Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, United States of America
⨯
Neil E. Caporaso ,

Contributed equally to this work with: Neil E. Caporaso, Jin Jen

Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, United States of America
⨯
[ ... ],
Jin Jen

Contributed equally to this work with: Neil E. Caporaso, Jin Jen

Affiliation Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, United States of America
⨯
[ view all ]
[ view less ]

Gene Expression Signature of Cigarette Smoking and Its Role in Lung Adenocarcinoma Development and Survival

Maria Teresa Landi,
Tatiana Dracheva,
Melissa Rotunno,
Jonine D. Figueroa,
Huaitian Liu,
Abhijit Dasgupta,
Felecia E. Mann,
Junya Fukuoka,
Megan Hames,
Andrew W. Bergen

Published: February 20, 2008
https://doi.org/10.1371/journal.pone.0001651

Reader Comments

Post a new comment on this article

Media Coverage of This Article

Posted by PLOS_ONE_Group on 08 Feb 2013 at 21:14 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: NIH Research Matters
Title: “Smoking Alters Gene Activity in Lungs and Tumors - National Institutes of Health (NIH)”
http://www.nih.gov/resear...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS ONE Staff

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Lung and intrathoracic tumors
Is the Subject Area "Lung and intrathoracic tumors" applicable to this article?

Thanks for your feedback.
Smoking habits
Is the Subject Area "Smoking habits" applicable to this article?

Thanks for your feedback.
Adenocarcinoma of the lung
Is the Subject Area "Adenocarcinoma of the lung" applicable to this article?

Thanks for your feedback.
Secondary lung tumors
Is the Subject Area "Secondary lung tumors" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Differentiated tumors
Is the Subject Area "Differentiated tumors" applicable to this article?

Thanks for your feedback.
Adenocarcinoma
Is the Subject Area "Adenocarcinoma" applicable to this article?

Thanks for your feedback.
Microarrays
Is the Subject Area "Microarrays" applicable to this article?

Thanks for your feedback.

Gene Expression Signature of Cigarette Smoking and Its Role in Lung Adenocarcinoma Development and Survival

Gene Expression Signature of Cigarette Smoking and Its Role in Lung Adenocarcinoma Development and Survival

Reader Comments

Post Your Discussion Comment

Why should this posting be reviewed?

Thank You!

Media Coverage of This Article

Posted by PLOS_ONE_Group on 08 Feb 2013 at 21:14 GMT