Gene Expression in Human Hippocampus from Cocaine Abusers Identifies Genes which Regulate Extracellular Matrix Remodeling

Deborah C. Mash; Jarlath ffrench-Mullen; Nikhil Adi; Yujing Qin; Andrew Buck; John Pablo

doi:10.1371/journal.pone.0001187

Loading metrics

Open Access

Peer-reviewed

Research Article

Gene Expression in Human Hippocampus from Cocaine Abusers Identifies Genes which Regulate Extracellular Matrix Remodeling

Deborah C. Mash ,

*To whom correspondence should be addressed. E-mail: dmash@med.miami.edu

Affiliations Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida, United States of America, Department of Cellular and Molecular Pharmacology, Miller School of Medicine, University of Miami, Miami, Florida, United States of America
⨯
Jarlath ffrench-Mullen,

Affiliation GeneLogic, Inc., Gaithersburg, Maryland, United States of America
⨯
Nikhil Adi,

Affiliation Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida, United States of America
⨯
Yujing Qin,

Affiliation Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida, United States of America
⨯
Andrew Buck,

Affiliation Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida, United States of America
⨯
John Pablo

Affiliation Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida, United States of America
⨯

Gene Expression in Human Hippocampus from Cocaine Abusers Identifies Genes which Regulate Extracellular Matrix Remodeling

Deborah C. Mash,
Jarlath ffrench-Mullen,
Nikhil Adi,
Yujing Qin,
Andrew Buck,
John Pablo

Published: November 14, 2007
https://doi.org/10.1371/journal.pone.0001187

Reader Comments

Post a new comment on this article

strange zymography

Posted by Ardan on 16 Nov 2007 at 19:06 GMT

Why in the zymography of the figure 5B MMP-9 appear indicated under MMP-2 if MMP-2 has a molecular weight of 72 kDa and MMP-9 has a molecular weight of 92 kDa?

RE: strange zymography

dmash replied to Ardan on 17 Dec 2007 at 11:42 GMT

In figure 5, the gel zymography in panel B was flipped in orientation so that it would match with the format shown in panel A for the Western blot. As Ardan rightly noted, the higher molecular weight band for MMP9 would run above the lower molecular weight band for MPP2. However, the figure legends points out the correct molecular weights for the two bands in panel B. We regret this confusion.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cocaine
Is the Subject Area "Cocaine" applicable to this article?

Thanks for your feedback.
Hippocampus
Is the Subject Area "Hippocampus" applicable to this article?

Thanks for your feedback.
Drug abuse
Is the Subject Area "Drug abuse" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Extracellular matrix proteins
Is the Subject Area "Extracellular matrix proteins" applicable to this article?

Thanks for your feedback.
Extracellular matrix
Is the Subject Area "Extracellular matrix" applicable to this article?

Thanks for your feedback.
Microarrays
Is the Subject Area "Microarrays" applicable to this article?

Thanks for your feedback.
Gene regulation
Is the Subject Area "Gene regulation" applicable to this article?

Thanks for your feedback.

Gene Expression in Human Hippocampus from Cocaine Abusers Identifies Genes which Regulate Extracellular Matrix Remodeling

Gene Expression in Human Hippocampus from Cocaine Abusers Identifies Genes which Regulate Extracellular Matrix Remodeling

Reader Comments

Post Your Discussion Comment

Why should this posting be reviewed?

Thank You!

strange zymography

Posted by Ardan on 16 Nov 2007 at 19:06 GMT

RE: strange zymography

dmash replied to Ardan on 17 Dec 2007 at 11:42 GMT