A New Mixed-Backbone Oligonucleotide against Glucosylceramide Synthase Sensitizes Multidrug-Resistant Tumors to Apoptosis

Gauri A. Patwardhan; Qian-Jin Zhang; Dongmei Yin; Vineet Gupta; Jianxiong Bao; Can E. Senkal; Besim Ogretmen; Myles C. Cabot; Girish V. Shah; Paul W. Sylvester; S. Michal Jazwinski; Yong-Yu Liu

doi:10.1371/journal.pone.0006938

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Open Access

Peer-reviewed

Research Article

A New Mixed-Backbone Oligonucleotide against Glucosylceramide Synthase Sensitizes Multidrug-Resistant Tumors to Apoptosis

Gauri A. Patwardhan,

Affiliation Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, Monroe, Louisiana, United States of America
⨯
Qian-Jin Zhang,

Affiliation Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
⨯
Dongmei Yin,

Affiliations Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, Monroe, Louisiana, United States of America, Department of Biochemistry, Nantong University School of Medicine, Nantong, Jiangsu, China
⨯
Vineet Gupta,

Affiliation Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, Monroe, Louisiana, United States of America
⨯
Jianxiong Bao,

Affiliation Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
⨯
Can E. Senkal,

Affiliation Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Besim Ogretmen,

Affiliation Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Myles C. Cabot,

Affiliation Experimental Therapeutics, John Wayne Cancer Institute, Santa Monica, California, United States of America
⨯
Girish V. Shah,

Affiliation Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, Monroe, Louisiana, United States of America
⨯
Paul W. Sylvester,

Affiliation Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, Monroe, Louisiana, United States of America
⨯
S. Michal Jazwinski,

Affiliation Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, United States of America
⨯
Yong-Yu Liu

* E-mail: yliu@ulm.edu

Affiliation Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, Monroe, Louisiana, United States of America
⨯

A New Mixed-Backbone Oligonucleotide against Glucosylceramide Synthase Sensitizes Multidrug-Resistant Tumors to Apoptosis

Gauri A. Patwardhan,
Qian-Jin Zhang,
Dongmei Yin,
Vineet Gupta,
Jianxiong Bao,
Can E. Senkal,
Besim Ogretmen,
Myles C. Cabot,
Girish V. Shah,
Paul W. Sylvester

Published: September 9, 2009
https://doi.org/10.1371/journal.pone.0006938

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Posted by zheschen on 16 Nov 2009 at 23:48 GMT

It is an interesting manuscript. I love it.

No competing interests declared.

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A New Mixed-Backbone Oligonucleotide against Glucosylceramide Synthase Sensitizes Multidrug-Resistant Tumors to Apoptosis

A New Mixed-Backbone Oligonucleotide against Glucosylceramide Synthase Sensitizes Multidrug-Resistant Tumors to Apoptosis

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Posted by zheschen on 16 Nov 2009 at 23:48 GMT