Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design

Pratima Kunwar; Natalie Hawkins; Warren L. Dinges; Yi Liu; Erin E. Gabriel; David A. Swan; Claire E. Stevens; Janine Maenza; Ann C. Collier; James I. Mullins; Tomer Hertz; Xuesong Yu; Helen Horton

doi:10.1371/journal.pone.0064405

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Open Access

Peer-reviewed

Research Article

Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design

Pratima Kunwar,

Affiliations Viral Vaccine Program, Seattle Biomedical Research Institute, Seattle, Washington, United States of America, Department of Global Health, University of Washington School of Medicine, Seattle, Washington, United States of America
⨯
Natalie Hawkins,

Affiliation Statistical Center for HIV Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Warren L. Dinges,

Affiliations Viral Vaccine Program, Seattle Biomedical Research Institute, Seattle, Washington, United States of America, Polyclinic Infectious Disease, Seattle, Washington, United States of America
⨯
Yi Liu,

Affiliation Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America
⨯
Erin E. Gabriel,

Affiliation Statistical Center for HIV Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
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David A. Swan,

Affiliation Statistical Center for HIV Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
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Claire E. Stevens,

Affiliation Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America
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Janine Maenza,

Affiliation Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America
⨯
Ann C. Collier,

Affiliation Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America
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James I. Mullins,

Affiliations Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America, Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America, Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America
⨯
Tomer Hertz,

Affiliation Statistical Center for HIV Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
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Xuesong Yu,

Affiliation Statistical Center for HIV Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
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Helen Horton

* E-mail: helen.horton@seattlebiomed.org

Affiliations Viral Vaccine Program, Seattle Biomedical Research Institute, Seattle, Washington, United States of America, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America, Department of Global Health, University of Washington School of Medicine, Seattle, Washington, United States of America
⨯

Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design

Pratima Kunwar,
Natalie Hawkins,
Warren L. Dinges,
Yi Liu,
Erin E. Gabriel,
David A. Swan,
Claire E. Stevens,
Janine Maenza,
Ann C. Collier,
James I. Mullins

Published: May 31, 2013
https://doi.org/10.1371/journal.pone.0064405

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Pérez et. al. recently described similar results (smaller cohort, not as comprehensive)

Posted by AnnikaKarlsson on 10 Jun 2013 at 08:07 GMT

Perez CL, et. al. Targeting of conserved gag-epitopes in early HIV infection is associated with lower plasma viral load and slower CD4(+) T cell depletion. AIDS Res Hum Retroviruses. 2013 Mar;29(3):602-12. doi: 10.1089/AID.2012.0171. Epub 2013 Jan 8.

No competing interests declared.

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Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design

Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design

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Pérez et. al. recently described similar results (smaller cohort, not as comprehensive)

Posted by AnnikaKarlsson on 10 Jun 2013 at 08:07 GMT