The Neglected Intrinsic Resistome of Bacterial Pathogens

Alicia Fajardo; Nadia Martínez-Martín; María Mercadillo; Juan C. Galán; Bart Ghysels; Sandra Matthijs; Pierre Cornelis; Lutz Wiehlmann; Burkhard Tümmler; Fernando Baquero; José L. Martínez

doi:10.1371/journal.pone.0001619

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Research Article

The Neglected Intrinsic Resistome of Bacterial Pathogens

Alicia Fajardo,

Affiliation Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Cantoblanco, Madrid, Spain
⨯
Nadia Martínez-Martín,

Affiliation Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Cantoblanco, Madrid, Spain
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María Mercadillo,

Affiliation Unidad Asociada al Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC) “Resistencia a los antibióticos y virulencia bacteriana”, Hospital Ramón y Cajal, Madrid, Spain
⨯
Juan C. Galán,

Affiliations Unidad Asociada al Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC) “Resistencia a los antibióticos y virulencia bacteriana”, Hospital Ramón y Cajal, Madrid, Spain, CIBER Epidemiología y Salud Pública (CIBERESP), Hospital Ramón y Cajal, Madrid, Spain, Departamento de Microbiología, Hospital Ramón y Cajal, Madrid, Spain
⨯
Bart Ghysels,

Affiliation Laboratory of Microbial Interactions, Department of Molecular and Cellular Interactions, Flanders Interuniversity Institute for Biotechnology, Vrije Universiteit Brussel, Brussels, Belgium
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Sandra Matthijs,

Affiliation Laboratory of Microbial Interactions, Department of Molecular and Cellular Interactions, Flanders Interuniversity Institute for Biotechnology, Vrije Universiteit Brussel, Brussels, Belgium
⨯
Pierre Cornelis,

Affiliation Laboratory of Microbial Interactions, Department of Molecular and Cellular Interactions, Flanders Interuniversity Institute for Biotechnology, Vrije Universiteit Brussel, Brussels, Belgium
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Lutz Wiehlmann,

Affiliation Klinische Forschergruppe, Medizinische Hochschule Hannover, Hannover, Germany
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Burkhard Tümmler,

Affiliation Klinische Forschergruppe, Medizinische Hochschule Hannover, Hannover, Germany
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Fernando Baquero,

Affiliations Unidad Asociada al Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC) “Resistencia a los antibióticos y virulencia bacteriana”, Hospital Ramón y Cajal, Madrid, Spain, CIBER Epidemiología y Salud Pública (CIBERESP), Hospital Ramón y Cajal, Madrid, Spain, Departamento de Microbiología, Hospital Ramón y Cajal, Madrid, Spain
⨯
José L. Martínez

*To whom correspondence should be addressed. E-mail: jlmtnez@cnb.uam.es

Affiliations Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Cantoblanco, Madrid, Spain, Unidad Asociada al Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC) “Resistencia a los antibióticos y virulencia bacteriana”, Hospital Ramón y Cajal, Madrid, Spain, CIBER Epidemiología y Salud Pública (CIBERESP), Hospital Ramón y Cajal, Madrid, Spain
⨯

The Neglected Intrinsic Resistome of Bacterial Pathogens

Alicia Fajardo,
Nadia Martínez-Martín,
María Mercadillo,
Juan C. Galán,
Bart Ghysels,
Sandra Matthijs,
Pierre Cornelis,
Lutz Wiehlmann,
Burkhard Tümmler,
Fernando Baquero

Published: February 20, 2008
https://doi.org/10.1371/journal.pone.0001619

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Referee comments: Referee 2 (Gerry Wright)

Posted by PLOS_ONE_Group on 25 Feb 2008 at 12:11 GMT

Referee 2's review (Gerry Wright):

This is a valuable addition to the growing literature that indicates that antibiotic resistance, like antibiotic action, is multifactorial. The results are thought provoking and important as we consider how to develop the next generations of antibiotics.

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N.B. These are the comments made by the referee when reviewing an earlier version of this paper. Prior to publication the manuscript has been revised in light of these comments and to address other editorial requirements.

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The Neglected Intrinsic Resistome of Bacterial Pathogens

The Neglected Intrinsic Resistome of Bacterial Pathogens

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Referee comments: Referee 2 (Gerry Wright)

Posted by PLOS_ONE_Group on 25 Feb 2008 at 12:11 GMT