The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

Stephanie J. Soscia; James E. Kirby; Kevin J. Washicosky; Stephanie M. Tucker; Martin Ingelsson; Bradley Hyman; Mark A. Burton; Lee E. Goldstein; Scott Duong; Rudolph E. Tanzi; Robert D. Moir

doi:10.1371/journal.pone.0009505

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Research Article

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

Stephanie J. Soscia,

Affiliations Genetics and Aging Research Unit, Mass General Institute for Neurodegenerative Disease and Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts, United States of America
⨯
James E. Kirby,

Affiliation Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
⨯
Kevin J. Washicosky,

Affiliation Genetics and Aging Research Unit, Mass General Institute for Neurodegenerative Disease and Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Stephanie M. Tucker,

Affiliation Genetics and Aging Research Unit, Mass General Institute for Neurodegenerative Disease and Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Martin Ingelsson,

Affiliation Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden
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Bradley Hyman,

Affiliations Genetics and Aging Research Unit, Mass General Institute for Neurodegenerative Disease and Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Mark A. Burton,

Affiliations Molecular Aging and Developmental Laboratory, Photonics Center, College of Engineering, Boston University School of Medicine, Boston University, Boston, Massachusetts, United States of America, Boston University Alzheimer's Disease Center, Boston University, Boston, Massachusetts, United States of America
⨯
Lee E. Goldstein,

Affiliations Molecular Aging and Developmental Laboratory, Photonics Center, College of Engineering, Boston University School of Medicine, Boston University, Boston, Massachusetts, United States of America, Boston University Alzheimer's Disease Center, Boston University, Boston, Massachusetts, United States of America
⨯
Scott Duong,

Affiliation Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
⨯
Rudolph E. Tanzi ,

* E-mail: tanzi@helix.mgh.harvard.edu

Affiliations Genetics and Aging Research Unit, Mass General Institute for Neurodegenerative Disease and Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Robert D. Moir

Affiliations Genetics and Aging Research Unit, Mass General Institute for Neurodegenerative Disease and Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

Stephanie J. Soscia,
James E. Kirby,
Kevin J. Washicosky,
Stephanie M. Tucker,
Martin Ingelsson,
Bradley Hyman,
Mark A. Burton,
Lee E. Goldstein,
Scott Duong,
Rudolph E. Tanzi

Published: March 3, 2010
https://doi.org/10.1371/journal.pone.0009505

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Evidence of AntiViral Activity

Posted by Eli-Kammerman on 07 Sep 2010 at 18:05 GMT

Acyclovir or Abeta42 peptides attenuate HSV-1-induced miRNA-146a levels in human primary brain cells.

Neuroreport. 2010 Oct 6;21(14):922-927.

PMID: 20683212

No competing interests declared.

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The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

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Evidence of AntiViral Activity

Posted by Eli-Kammerman on 07 Sep 2010 at 18:05 GMT