Genome-Wide Characterization of Pancreatic Adenocarcinoma Patients Using Next Generation Sequencing

Winnie S. Liang; David W. Craig; John Carpten; Mitesh J. Borad; Michael J. Demeure; Glen J. Weiss; Tyler Izatt; Shripad Sinari; Alexis Christoforides; Jessica Aldrich; Ahmet Kurdoglu; Michael Barrett; Lori Phillips; Hollie Benson; Waibhav Tembe; Esteban Braggio; Jeffrey A. Kiefer; Christophe Legendre; Richard Posner; Galen H. Hostetter; Angela Baker; Jan B. Egan; Haiyong Han; Douglas Lake; Edward C. Stites; Ramesh K. Ramanathan; Rafael Fonseca; A. Keith Stewart; Daniel Von Hoff

doi:10.1371/journal.pone.0043192

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Peer-reviewed

Research Article

Genome-Wide Characterization of Pancreatic Adenocarcinoma Patients Using Next Generation Sequencing

Winnie S. Liang ,

Contributed equally to this work with: Winnie S. Liang, David W. Craig, John Carpten, Mitesh J. Borad

Affiliation Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America
⨯
David W. Craig ,

Contributed equally to this work with: Winnie S. Liang, David W. Craig, John Carpten, Mitesh J. Borad

Affiliation Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America
⨯
John Carpten ,

Contributed equally to this work with: Winnie S. Liang, David W. Craig, John Carpten, Mitesh J. Borad

Affiliation Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America
⨯
Mitesh J. Borad ,

Contributed equally to this work with: Winnie S. Liang, David W. Craig, John Carpten, Mitesh J. Borad

Affiliation Mayo Clinic, Scottsdale, Arizona, United States of America
⨯
Michael J. Demeure,

Affiliations Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America, Virginia G. Piper Cancer Center Clinical Trials, Scottsdale Healthcare, Scottsdale, Arizona, United States of America
⨯
Glen J. Weiss,

Affiliations Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America, Virginia G. Piper Cancer Center Clinical Trials, Scottsdale Healthcare, Scottsdale, Arizona, United States of America
⨯
Tyler Izatt,

Affiliation Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America
⨯
Shripad Sinari,

Affiliation Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America
⨯
Alexis Christoforides,

Affiliation Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America
⨯
Jessica Aldrich,

Affiliation Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America
⨯
Ahmet Kurdoglu,

Affiliation Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America
⨯
Michael Barrett,

Affiliation Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America
⨯
Lori Phillips,

Affiliation Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America
⨯
Hollie Benson,

Affiliation Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America
⨯
Waibhav Tembe,

Affiliation Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America
⨯
Esteban Braggio,

Affiliation Mayo Clinic, Scottsdale, Arizona, United States of America
⨯
Jeffrey A. Kiefer,

Affiliation Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America
⨯
Christophe Legendre,

Affiliation Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America
⨯
Richard Posner,

Affiliation Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America
⨯
Galen H. Hostetter,

Affiliation Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America
⨯
Angela Baker,

Affiliation Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America
⨯
Jan B. Egan,

Affiliations Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America, Mayo Clinic, Scottsdale, Arizona, United States of America
⨯
Haiyong Han,

Affiliation Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America
⨯
Douglas Lake,

Affiliation Arizona State University, Tempe, Arizona, United States of America
⨯
Edward C. Stites,

Affiliation Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America
⨯
Ramesh K. Ramanathan,

Affiliations Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America, Virginia G. Piper Cancer Center Clinical Trials, Scottsdale Healthcare, Scottsdale, Arizona, United States of America
⨯
Rafael Fonseca,

Affiliation Mayo Clinic, Scottsdale, Arizona, United States of America
⨯
A. Keith Stewart,

Affiliation Mayo Clinic, Scottsdale, Arizona, United States of America
⨯
[ ... ],
Daniel Von Hoff

* E-mail: dvh@tgen.org

Affiliations Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America, Mayo Clinic, Scottsdale, Arizona, United States of America, Virginia G. Piper Cancer Center Clinical Trials, Scottsdale Healthcare, Scottsdale, Arizona, United States of America
⨯
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Genome-Wide Characterization of Pancreatic Adenocarcinoma Patients Using Next Generation Sequencing

Winnie S. Liang,
David W. Craig,
John Carpten,
Mitesh J. Borad,
Michael J. Demeure,
Glen J. Weiss,
Tyler Izatt,
Shripad Sinari,
Alexis Christoforides,
Jessica Aldrich

Published: October 10, 2012
https://doi.org/10.1371/journal.pone.0043192

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Update to NCBI data accession

Posted by wliang on 15 Jan 2013 at 17:35 GMT

Original text:
NCBI (National Center for Biotechnology Information) SRA (Sequence Read Archive) accession numbers for each patient are as follows—patient 1 DNA: SRS334038, SRS334039; patient 2 DNA: SRS334040, SRS334041; patient 2 RNA: SRS348787; patient 3 DNA: SRS334042, SRS334045; patient 3 RNA: SRS348788; pancreas RNA control: SRS334047).

Corrected text:
The NCBI (National Center for Biotechnology Information) dbGaP study accession number for the data described in this study is phs000550.v1.p1. SRA (Sequence Read Archive) accession numbers are as follows:
Patient 1 tumor DNA: SRS372474
Patient 1 germline DNA: SRS372475
Patient 2 tumor DNA: SRS372477
Patient 2 germline DNA: SRS372476
Patient 3 tumor DNA: SRS372478
Patient 3 germline DNA: SRS372481
Patient 2 tumor RNA: SRS372479
Patient 3 tumor RNA: SRS372480
Pancreas RNA control: SRS372482

No competing interests declared.

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Genome-Wide Characterization of Pancreatic Adenocarcinoma Patients Using Next Generation Sequencing

Genome-Wide Characterization of Pancreatic Adenocarcinoma Patients Using Next Generation Sequencing

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Update to NCBI data accession

Posted by wliang on 15 Jan 2013 at 17:35 GMT