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Posted by PLOS_CompBiol on 17 Feb 2009 at 11:36 GMT

This phylogenetic method (known as constraint analysis) is powerful and was recently used to gain insight into the origin of cellular superkingdoms and viruses
http://plosone.org/article/info:doi/10.1371/journal.pone.0002799#article1.body1.sec1.p3

This work is available in PLoS Computational Biology at: http://www.ploscompbiol.org/doi/pcbi.1000018.