The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

Stephanie J. Soscia; James E. Kirby; Kevin J. Washicosky; Stephanie M. Tucker; Martin Ingelsson; Bradley Hyman; Mark A. Burton; Lee E. Goldstein; Scott Duong; Rudolph E. Tanzi; Robert D. Moir

doi:10.1371/journal.pone.0009505

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Research Article

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

Stephanie J. Soscia,

Affiliations Genetics and Aging Research Unit, Mass General Institute for Neurodegenerative Disease and Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts, United States of America
⨯
James E. Kirby,

Affiliation Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
⨯
Kevin J. Washicosky,

Affiliation Genetics and Aging Research Unit, Mass General Institute for Neurodegenerative Disease and Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Stephanie M. Tucker,

Affiliation Genetics and Aging Research Unit, Mass General Institute for Neurodegenerative Disease and Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Martin Ingelsson,

Affiliation Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden
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Bradley Hyman,

Affiliations Genetics and Aging Research Unit, Mass General Institute for Neurodegenerative Disease and Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Mark A. Burton,

Affiliations Molecular Aging and Developmental Laboratory, Photonics Center, College of Engineering, Boston University School of Medicine, Boston University, Boston, Massachusetts, United States of America, Boston University Alzheimer's Disease Center, Boston University, Boston, Massachusetts, United States of America
⨯
Lee E. Goldstein,

Affiliations Molecular Aging and Developmental Laboratory, Photonics Center, College of Engineering, Boston University School of Medicine, Boston University, Boston, Massachusetts, United States of America, Boston University Alzheimer's Disease Center, Boston University, Boston, Massachusetts, United States of America
⨯
Scott Duong,

Affiliation Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
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Rudolph E. Tanzi ,

* E-mail: tanzi@helix.mgh.harvard.edu

Affiliations Genetics and Aging Research Unit, Mass General Institute for Neurodegenerative Disease and Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Robert D. Moir

Affiliations Genetics and Aging Research Unit, Mass General Institute for Neurodegenerative Disease and Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

Stephanie J. Soscia,
James E. Kirby,
Kevin J. Washicosky,
Stephanie M. Tucker,
Martin Ingelsson,
Bradley Hyman,
Mark A. Burton,
Lee E. Goldstein,
Scott Duong,
Rudolph E. Tanzi

Published: March 3, 2010
https://doi.org/10.1371/journal.pone.0009505

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Media Coverage of this Article

Posted by PLOS_ONE_Group on 03 Sep 2013 at 22:56 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: Bloomberg.com
Title: “Brain Amyloid Has Antibiotic Role in Alzheimers, Study Finds - Bloomberg”
http://www.bloomberg.com/...

Publication: Chemistry World
Title: “Microbes implicated in Alzheimer's”
http://www.rsc.org/chemis...

Publication: Harvard Gazette
Title: “Alzheimers-associated protein may be part of the innate immune system | Harvard Gazette”
http://news.harvard.edu/g...

Publication: The Dana Foundation
Title: “Alzheimers Protein May Be a Natural Immune Protein - Dana Foundation”
http://www.dana.org/news/...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS ONE Staff

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The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

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Media Coverage of this Article

Posted by PLOS_ONE_Group on 03 Sep 2013 at 22:56 GMT