MHC Mismatch Inhibits Neurogenesis and Neuron Maturation in Stem Cell Allografts

Zhiguo Chen; Lori K. Phillips; Elizabeth Gould; Jay Campisi; Star W. Lee; Brandi K. Ormerod; Monika Zwierzchoniewska; Olivia M. Martinez; Theo D. Palmer

doi:10.1371/journal.pone.0014787

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Peer-reviewed

Research Article

MHC Mismatch Inhibits Neurogenesis and Neuron Maturation in Stem Cell Allografts

Zhiguo Chen ,

* E-mail: zchen1@stanford.edu

Current address: Merrimack College, North Andover, Massachusetts, United States of America

Affiliation Stanford Institute for Stem Cell Biology and Regenerative Medicine and Department of Neurosurgery, Stanford, California, United States of America
⨯
Lori K. Phillips,

Affiliation Department of Surgery, Stanford University School of Medicine, Stanford, California, United States of America
⨯
Elizabeth Gould,

Affiliation Stanford Institute for Stem Cell Biology and Regenerative Medicine and Department of Neurosurgery, Stanford, California, United States of America
⨯
Jay Campisi,

Affiliation Department of Surgery, Stanford University School of Medicine, Stanford, California, United States of America
⨯
Star W. Lee,

Current address: Salk Institute, La Jolla, California, United States of America

Affiliation Stanford Institute for Stem Cell Biology and Regenerative Medicine and Department of Neurosurgery, Stanford, California, United States of America
⨯
Brandi K. Ormerod,

Current address: University of Florida, Gainesville, Florida, United States of America

Affiliation Stanford Institute for Stem Cell Biology and Regenerative Medicine and Department of Neurosurgery, Stanford, California, United States of America
⨯
Monika Zwierzchoniewska,

Affiliation Department of Surgery, Stanford University School of Medicine, Stanford, California, United States of America
⨯
Olivia M. Martinez,

Affiliation Department of Surgery, Stanford University School of Medicine, Stanford, California, United States of America
⨯
Theo D. Palmer

Affiliation Stanford Institute for Stem Cell Biology and Regenerative Medicine and Department of Neurosurgery, Stanford, California, United States of America
⨯

MHC Mismatch Inhibits Neurogenesis and Neuron Maturation in Stem Cell Allografts

Zhiguo Chen,
Lori K. Phillips,
Elizabeth Gould,
Jay Campisi,
Star W. Lee,
Brandi K. Ormerod,
Monika Zwierzchoniewska,
Olivia M. Martinez,
Theo D. Palmer

Published: March 30, 2011
https://doi.org/10.1371/journal.pone.0014787

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Publisher's Note: Missing corresponding author

Posted by PLOS_ONE_Group on 05 Apr 2011 at 17:06 GMT

The role of histocompatibility and immune recognition in stem cell transplant therapy has been controversial, with many reports arguing that undifferentiated stem cells are protected from immune recognition due to the absence of major histocompatibility complex (MHC) markers. This argument is even more persuasive in transplantation into the central nervous system (CNS) where the graft rejection response is minimal.
http://plosone.org/article/info:doi/10.1371/journal.pone.0014787#article1.front1.article-meta1.abstract1.sec1.p1

Theo D. Palmer should have corresponding authorship. Corresponding email is: tpalmer@stanford.edu.

No competing interests declared.

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MHC Mismatch Inhibits Neurogenesis and Neuron Maturation in Stem Cell Allografts

MHC Mismatch Inhibits Neurogenesis and Neuron Maturation in Stem Cell Allografts

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Publisher's Note: Missing corresponding author

Posted by PLOS_ONE_Group on 05 Apr 2011 at 17:06 GMT