A Non-VH1-69 Heterosubtypic Neutralizing Human Monoclonal Antibody Protects Mice against H1N1 and H5N1 Viruses

Donata De Marco; Nicola Clementi; Nicasio Mancini; Laura Solforosi; Guisella J. Moreno; Xiangjie Sun; Terrence M. Tumpey; Larisa V. Gubareva; Vasiliy Mishin; Massimo Clementi; Roberto Burioni

doi:10.1371/journal.pone.0034415

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Research Article

A Non-VH1-69 Heterosubtypic Neutralizing Human Monoclonal Antibody Protects Mice against H1N1 and H5N1 Viruses

Donata De Marco ,

Contributed equally to this work with: Donata De Marco, Nicola Clementi, Nicasio Mancini

Affiliation Laboratory of Microbiology and Virology, Vita-Salute San Raffaele University, Milan, Italy
⨯
Nicola Clementi ,

Contributed equally to this work with: Donata De Marco, Nicola Clementi, Nicasio Mancini

Affiliation Laboratory of Microbiology and Virology, Vita-Salute San Raffaele University, Milan, Italy
⨯
Nicasio Mancini ,

Contributed equally to this work with: Donata De Marco, Nicola Clementi, Nicasio Mancini

Affiliation Laboratory of Microbiology and Virology, Vita-Salute San Raffaele University, Milan, Italy
⨯
Laura Solforosi,

Affiliation Laboratory of Microbiology and Virology, Vita-Salute San Raffaele University, Milan, Italy
⨯
Guisella J. Moreno,

Affiliation Laboratory of Microbiology and Virology, Vita-Salute San Raffaele University, Milan, Italy
⨯
Xiangjie Sun,

Affiliation Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
⨯
Terrence M. Tumpey,

Affiliation Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
⨯
Larisa V. Gubareva,

Affiliation Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
⨯
Vasiliy Mishin,

Affiliation Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
⨯
Massimo Clementi,

Affiliation Laboratory of Microbiology and Virology, Vita-Salute San Raffaele University, Milan, Italy
⨯
Roberto Burioni

* E-mail: burioni.roberto@hsr.it

Affiliation Laboratory of Microbiology and Virology, Vita-Salute San Raffaele University, Milan, Italy
⨯

A Non-VH1-69 Heterosubtypic Neutralizing Human Monoclonal Antibody Protects Mice against H1N1 and H5N1 Viruses

Donata De Marco,
Nicola Clementi,
Nicasio Mancini,
Laura Solforosi,
Guisella J. Moreno,
Xiangjie Sun,
Terrence M. Tumpey,
Larisa V. Gubareva,
Vasiliy Mishin,
Massimo Clementi

Published: April 4, 2012
https://doi.org/10.1371/journal.pone.0034415

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PDB structure

Posted by fkrammer on 13 Apr 2012 at 11:11 GMT

What is the code for the PDB structure shown in Fig. 4. As far as I know there is no structure of the A/PR/8/34 HA. Was this specifically done for this study?

No competing interests declared.

RE: PDB structure

nclementi2 replied to fkrammer on 07 Mar 2014 at 11:40 GMT

RCSB Protein Data Bank PDB I: 1RU7 (A/PR/8/34) deposition 11 december 2003
The same paper describing A/PR/8/34 HA describes also 1918 HA and 1930 swine H1 strain HA.

No competing interests declared.

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A Non-VH1-69 Heterosubtypic Neutralizing Human Monoclonal Antibody Protects Mice against H1N1 and H5N1 Viruses

A Non-VH1-69 Heterosubtypic Neutralizing Human Monoclonal Antibody Protects Mice against H1N1 and H5N1 Viruses

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PDB structure

Posted by fkrammer on 13 Apr 2012 at 11:11 GMT

RE: PDB structure

nclementi2 replied to fkrammer on 07 Mar 2014 at 11:40 GMT