A CNGB1 Frameshift Mutation in Papillon and Phalène Dogs with Progressive Retinal Atrophy

Saija J. Ahonen; Meharji Arumilli; Hannes Lohi

doi:10.1371/journal.pone.0072122

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Peer-reviewed

Research Article

A CNGB1 Frameshift Mutation in Papillon and Phalène Dogs with Progressive Retinal Atrophy

Saija J. Ahonen,

Affiliations Department of Veterinary Biosciences and Research Programs Unit, Molecular Neurology, University of Helsinki, Helsinki, Finland, The Folkhälsan Institute of Genetics, Helsinki, Finland
⨯
Meharji Arumilli,

Affiliations Department of Veterinary Biosciences and Research Programs Unit, Molecular Neurology, University of Helsinki, Helsinki, Finland, The Folkhälsan Institute of Genetics, Helsinki, Finland
⨯
Hannes Lohi

* E-mail: hannes.lohi@helsinki.fi

Affiliations Department of Veterinary Biosciences and Research Programs Unit, Molecular Neurology, University of Helsinki, Helsinki, Finland, The Folkhälsan Institute of Genetics, Helsinki, Finland
⨯

A CNGB1 Frameshift Mutation in Papillon and Phalène Dogs with Progressive Retinal Atrophy

Saija J. Ahonen,
Meharji Arumilli,
Hannes Lohi

Published: August 28, 2013
https://doi.org/10.1371/journal.pone.0072122

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PRA in our Papillon breeding stock

Posted by irenelester on 24 Feb 2014 at 16:13 GMT

Hello:
I am a Canadian Papillon breeder who very recently found out about the DNA testing for PRA1 in Papillons.
Having bred one of my females to a particular stud (which I do not own) in 2013, and wishing to do a repeat breeding, I had both animals tested. To our shock BOTH proved to be carriers.
Now to carry on with our combined breeding stock, we are finding the added costs overwhelming. I have 2 more females the need to be tested, the other breeder has about 6 females to test (I paid for her stud to be tested as she just could not afford to do so herself).
My question then is: is there any way we can contribute to your research, and can you help us by testing our dogs for us so we may select the right animals for future breedings?
Irene Lester
Burlington, Ontario
ilester@sympatico.ca
www.papillondogs.ca

No competing interests declared.

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Dogs
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Frameshift mutation
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Pets and companion animals
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Retinal degeneration
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Single nucleotide polymorphisms
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Homozygosity
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Photoreceptors
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A CNGB1 Frameshift Mutation in Papillon and Phalène Dogs with Progressive Retinal Atrophy

A CNGB1 Frameshift Mutation in Papillon and Phalène Dogs with Progressive Retinal Atrophy

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PRA in our Papillon breeding stock

Posted by irenelester on 24 Feb 2014 at 16:13 GMT