Instrumental Variable Estimation of the Causal Effect of Plasma 25-Hydroxy-Vitamin D on Colorectal Cancer Risk: A Mendelian Randomization Analysis

Evropi Theodoratou; Tom Palmer; Lina Zgaga; Susan M. Farrington; Paul McKeigue; Farhat V. N. Din; Albert Tenesa; George Davey-Smith; Malcolm G. Dunlop; Harry Campbell

doi:10.1371/journal.pone.0037662

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Peer-reviewed

Research Article

Instrumental Variable Estimation of the Causal Effect of Plasma 25-Hydroxy-Vitamin D on Colorectal Cancer Risk: A Mendelian Randomization Analysis

Evropi Theodoratou ,

* E-mail: E.Theodoratou@ed.ac.uk

Affiliations Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom, MRC Human Genetics Unit, Colon Cancer Genetics Group and Academic Coloproctology, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital Edinburgh, United Kingdom
⨯
Tom Palmer,

Affiliation MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
⨯
Lina Zgaga,

Affiliations Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom, MRC Human Genetics Unit, Colon Cancer Genetics Group and Academic Coloproctology, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital Edinburgh, United Kingdom, Andrija Stampar School of Public Health, Medical School, University of Zagreb, Zagreb, Croatia
⨯
Susan M. Farrington,

Affiliation MRC Human Genetics Unit, Colon Cancer Genetics Group and Academic Coloproctology, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital Edinburgh, United Kingdom
⨯
Paul McKeigue,

Affiliation Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom
⨯
Farhat V. N. Din,

Affiliation MRC Human Genetics Unit, Colon Cancer Genetics Group and Academic Coloproctology, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital Edinburgh, United Kingdom
⨯
Albert Tenesa,

Affiliations MRC Human Genetics Unit, Colon Cancer Genetics Group and Academic Coloproctology, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital Edinburgh, United Kingdom, The Roslin Institute, The University of Edinburgh, Easter Bush, Roslin, Scotland
⨯
George Davey-Smith,

Affiliation MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
⨯
Malcolm G. Dunlop,

Affiliation MRC Human Genetics Unit, Colon Cancer Genetics Group and Academic Coloproctology, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital Edinburgh, United Kingdom
⨯
Harry Campbell

Affiliation Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom
⨯

Instrumental Variable Estimation of the Causal Effect of Plasma 25-Hydroxy-Vitamin D on Colorectal Cancer Risk: A Mendelian Randomization Analysis

Evropi Theodoratou,
Tom Palmer,
Lina Zgaga,
Susan M. Farrington,
Paul McKeigue,
Farhat V. N. Din,
Albert Tenesa,
George Davey-Smith,
Malcolm G. Dunlop,
Harry Campbell

Published: June 6, 2012
https://doi.org/10.1371/journal.pone.0037662

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Publisher's Note: Missing reference and citations.

Posted by PLOS_ONE_Group on 27 Sep 2012 at 16:55 GMT

2) an upstream allele score that combined the SNPs rs12785878 and rs10741657 and 3) a downstream allele score that combined the SNPs rs2282679 and rs6013897
http://plosone.org/article/info:doi/10.1371/journal.pone.0037662#article1.body1.sec3.sec3.p4

The following reference is missing from the published article:

Berry DJ, Vimaleswaran KS, Whittaker JC, Hingorani AD, Hyppönen E (2012) Evaluation of Genetic Markers as Instruments for Mendelian Randomization Studies on Vitamin D. PLoS ONE 7(5): e37465. doi:10.1371/journal.pone.0037465

The locations where this reference should be cited are in the last paragraph of Results following "an upstream allele score that combined the SNPs rs12785878 and rs10741657" and following "a downstream allele score that combined the SNPs rs2282679 and rs6013897".

No competing interests declared.

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Colorectal cancer
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Cancer risk factors
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Vitamin D
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Single nucleotide polymorphisms
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Instrumental variable analysis
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Vitamin D deficiency
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Cancer detection and diagnosis
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Instrumental Variable Estimation of the Causal Effect of Plasma 25-Hydroxy-Vitamin D on Colorectal Cancer Risk: A Mendelian Randomization Analysis

Instrumental Variable Estimation of the Causal Effect of Plasma 25-Hydroxy-Vitamin D on Colorectal Cancer Risk: A Mendelian Randomization Analysis

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Publisher's Note: Missing reference and citations.

Posted by PLOS_ONE_Group on 27 Sep 2012 at 16:55 GMT