A Functional Polymorphism in the 5HTR2C Gene Associated with Stress Responses Also Predicts Incident Cardiovascular Events

Beverly H. Brummett; Michael A. Babyak; Rong Jiang; Svati H. Shah; Richard C. Becker; Carol Haynes; Megan Chryst-Ladd; Damian M. Craig; Elizabeth R. Hauser; Ilene C. Siegler; Cynthia M. Kuhn; Abanish Singh; Redford B. Williams

doi:10.1371/journal.pone.0082781

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Open Access

Peer-reviewed

Research Article

A Functional Polymorphism in the 5HTR2C Gene Associated with Stress Responses Also Predicts Incident Cardiovascular Events

Beverly H. Brummett ,

* E-mail: brummett@duke.edu

Affiliation Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Michael A. Babyak,

Affiliation Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Rong Jiang,

Affiliation Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Svati H. Shah,

Affiliations Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America, Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Richard C. Becker,

Affiliations Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America, Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Carol Haynes,

Affiliation Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Megan Chryst-Ladd,

Affiliation Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Damian M. Craig,

Affiliation Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Elizabeth R. Hauser,

Affiliations Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America, Epidemiological Research and Information Center, Durham VA Medical Center, Durham, North Carolina, United States of America
⨯
Ilene C. Siegler,

Affiliation Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Cynthia M. Kuhn,

Affiliations Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, United States of America, Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Abanish Singh,

Affiliation Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Redford B. Williams

Affiliation Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, United States of America
⨯

A Functional Polymorphism in the 5HTR2C Gene Associated with Stress Responses Also Predicts Incident Cardiovascular Events

Beverly H. Brummett,
Michael A. Babyak,
Rong Jiang,
Svati H. Shah,
Richard C. Becker,
Carol Haynes,
Megan Chryst-Ladd,
Damian M. Craig,
Elizabeth R. Hauser,
Ilene C. Siegler

Published: December 18, 2013
https://doi.org/10.1371/journal.pone.0082781

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Can someone who submitted a sample to 23andme see if they do or do not have this stress gene condition?

Posted by BruceAlmich on 14 Jan 2014 at 00:29 GMT

Non-genetic scientist here who submitted a genetic sample to 23andme last year. I'm wondering if there is anything that I can look for in their results that would help me spot whether or not I have this genetic condition. FDA cut off genetic reporting from 23andme last November but my family and I managed to get our results before the (temporary, hopefully) shutdown of their genetic reporting.

Thank you for considering a lay person's naïve question!

No competing interests declared.

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A Functional Polymorphism in the 5HTR2C Gene Associated with Stress Responses Also Predicts Incident Cardiovascular Events

A Functional Polymorphism in the 5HTR2C Gene Associated with Stress Responses Also Predicts Incident Cardiovascular Events

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Can someone who submitted a sample to 23andme see if they do or do not have this stress gene condition?

Posted by BruceAlmich on 14 Jan 2014 at 00:29 GMT