Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease

Eugenia Trushina; Emirhan Nemutlu; Song Zhang; Trace Christensen; Jon Camp; Janny Mesa; Ammar Siddiqui; Yasushi Tamura; Hiromi Sesaki; Thomas M. Wengenack; Petras P. Dzeja; Joseph F. Poduslo

doi:10.1371/journal.pone.0032737

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Open Access

Peer-reviewed

Research Article

Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease

Eugenia Trushina ,

* E-mail: Trushina.eugenia@mayo.edu

Affiliation Department of Molecular Pharmacology and Experimental Therapeutics and Neurology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Emirhan Nemutlu,

Affiliation Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Song Zhang,

Affiliation Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Trace Christensen,

Affiliation Electron Microscopy Core Facility, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Jon Camp,

Affiliation Biomedical Imaging Resource, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Janny Mesa,

Affiliation Department of Molecular Pharmacology and Experimental Therapeutics and Neurology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Ammar Siddiqui,

Affiliation Department of Molecular Pharmacology and Experimental Therapeutics and Neurology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Yasushi Tamura,

Affiliation Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Hiromi Sesaki,

Affiliation Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Thomas M. Wengenack,

Affiliation Departments of Neurology and Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Petras P. Dzeja,

Affiliation Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Joseph F. Poduslo

Affiliation Departments of Neurology and Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯

Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease

Eugenia Trushina,
Emirhan Nemutlu,
Song Zhang,
Trace Christensen,
Jon Camp,
Janny Mesa,
Ammar Siddiqui,
Yasushi Tamura,
Hiromi Sesaki,
Thomas M. Wengenack

Published: February 29, 2012
https://doi.org/10.1371/journal.pone.0032737

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American Health Assistance Foundation is now BrightFocus Foundation

Posted by agordon123 on 03 Apr 2013 at 17:44 GMT

As of 2013, BrightFocus Foundation is the new name for the American Health Assistance Foundation, which provided funding for this research.

No competing interests declared.

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Mitochondria
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Alzheimer's disease
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Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease

Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease

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American Health Assistance Foundation is now BrightFocus Foundation

Posted by agordon123 on 03 Apr 2013 at 17:44 GMT