Anti-Transforming Growth Factor ß Antibody Treatment Rescues Bone Loss and Prevents Breast Cancer Metastasis to Bone

Swati Biswas; Jeffry S. Nyman; JoAnn Alvarez; Anwesa Chakrabarti; Austin Ayres; Julie Sterling; James Edwards; Tapasi Rana; Rachelle Johnson; Daniel S. Perrien; Scott Lonning; Yu Shyr; Lynn M. Matrisian; Gregory R. Mundy

doi:10.1371/journal.pone.0027090

Loading metrics

Open Access

Peer-reviewed

Research Article

Anti-Transforming Growth Factor ß Antibody Treatment Rescues Bone Loss and Prevents Breast Cancer Metastasis to Bone

Swati Biswas ,

* E-mail: swati.biswas@vanderbilt.edu

Affiliations Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Jeffry S. Nyman,

Affiliation Department of Orthopedics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
JoAnn Alvarez,

Affiliation Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Anwesa Chakrabarti,

Affiliation Center for Bone Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Austin Ayres,

Affiliation Center for Bone Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Julie Sterling,

Affiliation Center for Bone Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
James Edwards,

Affiliation Center for Bone Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Tapasi Rana,

Affiliation Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Rachelle Johnson,

Affiliation Center for Bone Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Daniel S. Perrien,

Affiliations Center for Bone Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Orthopedics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Vanderbilt University Institute of Imaging Science, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Scott Lonning,

Affiliation Genzyme Corporation, Framingham, Massachusetts, United States of America
⨯
Yu Shyr,

Affiliation Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Lynn M. Matrisian,

Affiliation Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Gregory R. Mundy

Affiliations Center for Bone Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯

Anti-Transforming Growth Factor ß Antibody Treatment Rescues Bone Loss and Prevents Breast Cancer Metastasis to Bone

Swati Biswas,
Jeffry S. Nyman,
JoAnn Alvarez,
Anwesa Chakrabarti,
Austin Ayres,
Julie Sterling,
James Edwards,
Tapasi Rana,
Rachelle Johnson,
Daniel S. Perrien

Published: November 11, 2011
https://doi.org/10.1371/journal.pone.0027090

Reader Comments

Post a new comment on this article

Publisher's Note: Error in Affiliation Assignment

Posted by PLOS_ONE_Group on 18 Nov 2011 at 00:18 GMT

Breast
http://plosone.org/article/info:doi/10.1371/journal.pone.0027090#article1.front1.article-meta1.abstract1.p1

The affiliation of 2nd author Jeffry S. Nyman was incorrectly assigned. Jeffrey S. Nyman is affiliated with: Center for Bone Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America; VA Tennessee Valley Healthcare System, Nashville, Tennessee, United States of America; and the Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.

No competing interests declared.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Breast cancer
Is the Subject Area "Breast cancer" applicable to this article?

Thanks for your feedback.
Antibody therapy
Is the Subject Area "Antibody therapy" applicable to this article?

Thanks for your feedback.
Metastasis
Is the Subject Area "Metastasis" applicable to this article?

Thanks for your feedback.
Osteoclasts
Is the Subject Area "Osteoclasts" applicable to this article?

Thanks for your feedback.
Osteoblasts
Is the Subject Area "Osteoblasts" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Bone resorption
Is the Subject Area "Bone resorption" applicable to this article?

Thanks for your feedback.

Anti-Transforming Growth Factor ß Antibody Treatment Rescues Bone Loss and Prevents Breast Cancer Metastasis to Bone

Anti-Transforming Growth Factor ß Antibody Treatment Rescues Bone Loss and Prevents Breast Cancer Metastasis to Bone

Reader Comments

Post Your Discussion Comment

Why should this posting be reviewed?

Thank You!

Publisher's Note: Error in Affiliation Assignment

Posted by PLOS_ONE_Group on 18 Nov 2011 at 00:18 GMT