Cooperative Stimulation of Dendritic Cells by Cryptococcus neoformans Mannoproteins and CpG Oligodeoxynucleotides

Jennifer M. Dan; Jennifer P. Wang; Chrono K. Lee; Stuart M. Levitz

doi:10.1371/journal.pone.0002046

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Peer-reviewed

Research Article

Cooperative Stimulation of Dendritic Cells by Cryptococcus neoformans Mannoproteins and CpG Oligodeoxynucleotides

Jennifer M. Dan,

Affiliations Department of Microbiology and Immunology Training Program, Boston University School of Medicine, Boston, Massachusetts, United States of America, Division of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Jennifer P. Wang,

Affiliation Division of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Chrono K. Lee,

Affiliation Division of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Stuart M. Levitz

* E-mail: Stuart.Levitz@umassmed.edu

Affiliations Department of Microbiology and Immunology Training Program, Boston University School of Medicine, Boston, Massachusetts, United States of America, Division of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯

Cooperative Stimulation of Dendritic Cells by Cryptococcus neoformans Mannoproteins and CpG Oligodeoxynucleotides

Jennifer M. Dan,
Jennifer P. Wang,
Chrono K. Lee,
Stuart M. Levitz

Published: April 30, 2008
https://doi.org/10.1371/journal.pone.0002046

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Referee Comments: Referee 3

Posted by PLOS_ONE_Group on 01 May 2008 at 14:16 GMT

Referee 3's review:

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N.B. These are the comments made by the referee when reviewing an earlier version of this paper. Prior to publication, the manuscript has been revised in light of these comments and to address other editorial requirements.
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The purpose of this study on MP and TLR ligands that synergize to induce DC cytokines and T-cell responses is well defined. The data are clearly presented and analyzed and the conclusions are well supported.

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Cytokines
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Toll-like receptors
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T cells
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Mannose
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Cryptococcus neoformans
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Cooperative Stimulation of Dendritic Cells by Cryptococcus neoformans Mannoproteins and CpG Oligodeoxynucleotides

Cooperative Stimulation of Dendritic Cells by Cryptococcus neoformans Mannoproteins and CpG Oligodeoxynucleotides

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Referee Comments: Referee 3

Posted by PLOS_ONE_Group on 01 May 2008 at 14:16 GMT