Long-Term Upregulation of Inflammation and Suppression of Cell Proliferation in the Brain of Adult Rats Exposed to Traumatic Brain Injury Using the Controlled Cortical Impact Model

Sandra A. Acosta; Naoki Tajiri; Kazutaka Shinozuka; Hiroto Ishikawa; Bethany Grimmig; David Diamond; Paul R. Sanberg; Paula C. Bickford; Yuji Kaneko; Cesar V. Borlongan

doi:10.1371/journal.pone.0053376

Loading metrics

Open Access

Peer-reviewed

Research Article

Long-Term Upregulation of Inflammation and Suppression of Cell Proliferation in the Brain of Adult Rats Exposed to Traumatic Brain Injury Using the Controlled Cortical Impact Model

Sandra A. Acosta,

Affiliation Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, United States of America
⨯
Naoki Tajiri,

Affiliation Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, United States of America
⨯
Kazutaka Shinozuka,

Affiliation Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, United States of America
⨯
Hiroto Ishikawa,

Affiliation Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, United States of America
⨯
Bethany Grimmig,

Affiliations Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, United States of America, James A. Haley Veterans Affairs Hospital, Tampa, Florida, United States of America
⨯
David Diamond,

Affiliation Department of Psychology, University of South Florida, Tampa, Florida, United States of America
⨯
Paul R. Sanberg,

Affiliations Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, United States of America, Office of Research and Innovation, University of South Florida, Tampa, Florida, United States of America
⨯
Paula C. Bickford,

Affiliations Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, United States of America, James A. Haley Veterans Affairs Hospital, Tampa, Florida, United States of America
⨯
Yuji Kaneko,

Affiliation Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, United States of America
⨯
Cesar V. Borlongan

* E-mail: cborlong@health.usf.edu

Affiliation Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, United States of America
⨯

Long-Term Upregulation of Inflammation and Suppression of Cell Proliferation in the Brain of Adult Rats Exposed to Traumatic Brain Injury Using the Controlled Cortical Impact Model

Sandra A. Acosta,
Naoki Tajiri,
Kazutaka Shinozuka,
Hiroto Ishikawa,
Bethany Grimmig,
David Diamond,
Paul R. Sanberg,
Paula C. Bickford,
Yuji Kaneko,
Cesar V. Borlongan

Published: January 3, 2013
https://doi.org/10.1371/journal.pone.0053376

Reader Comments

Post a new comment on this article

Media Coverage of This Article

Posted by PLOS_ONE_Group on 14 Jan 2013 at 19:31 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: Medical Xpress
Title: “Researchers find long-term consequences for those suffering traumatic brain injury”
http://medicalxpress.com/...

Publication: Melodika
Title: “MELODIKA.net - Understanding the Stages of Traumatic Brain Injury”
http://www.melodika.net/i...

Publication: News Medical
Title: “Study investigates prolonged pathological outcomes of traumatic brain injury”
http://www.news-medical.n...

Publication: Science Daily
Title: “Long-term consequences for those suffering traumatic brain injury”
http://www.sciencedaily.c...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS ONE Staff

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Traumatic brain injury
Is the Subject Area "Traumatic brain injury" applicable to this article?

Thanks for your feedback.
Cell proliferation
Is the Subject Area "Cell proliferation" applicable to this article?

Thanks for your feedback.
Microglial cells
Is the Subject Area "Microglial cells" applicable to this article?

Thanks for your feedback.
Hippocampus
Is the Subject Area "Hippocampus" applicable to this article?

Thanks for your feedback.
Neuronal differentiation
Is the Subject Area "Neuronal differentiation" applicable to this article?

Thanks for your feedback.
Central nervous system
Is the Subject Area "Central nervous system" applicable to this article?

Thanks for your feedback.
Thalamus
Is the Subject Area "Thalamus" applicable to this article?

Thanks for your feedback.
Neostriatum
Is the Subject Area "Neostriatum" applicable to this article?

Thanks for your feedback.

Long-Term Upregulation of Inflammation and Suppression of Cell Proliferation in the Brain of Adult Rats Exposed to Traumatic Brain Injury Using the Controlled Cortical Impact Model

Long-Term Upregulation of Inflammation and Suppression of Cell Proliferation in the Brain of Adult Rats Exposed to Traumatic Brain Injury Using the Controlled Cortical Impact Model

Reader Comments

Post Your Discussion Comment

Why should this posting be reviewed?

Thank You!

Media Coverage of This Article

Posted by PLOS_ONE_Group on 14 Jan 2013 at 19:31 GMT