A New Slow Releasing, H2S Generating Compound, GYY4137 Relaxes Spontaneous and Oxytocin-Stimulated Contractions of Human and Rat Pregnant Myometrium

Hayley Robinson; Susan Wray

doi:10.1371/journal.pone.0046278

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Research Article

A New Slow Releasing, H₂S Generating Compound, GYY4137 Relaxes Spontaneous and Oxytocin-Stimulated Contractions of Human and Rat Pregnant Myometrium

Hayley Robinson,

Affiliation Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
⨯
Susan Wray

* E-mail: s.wray@liv.ac.uk

Affiliation Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
⨯

A New Slow Releasing, H₂S Generating Compound, GYY4137 Relaxes Spontaneous and Oxytocin-Stimulated Contractions of Human and Rat Pregnant Myometrium

Hayley Robinson,
Susan Wray

Published: September 27, 2012
https://doi.org/10.1371/journal.pone.0046278

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Diatomic gases hold may hold key to therapy

Posted by ahmedas on 27 Apr 2013 at 15:47 GMT

Excellent paper. Well designed. I am very glad to see that physiologists are looking again at second messenger gases in parturition and and preterm labor. This paper has identified another diatomic gas. Together with a similar study on CO/HO-1 (see our old paper in J Clin Invest 1998 Acevedo and Ahmed), I think the link has been established between CO/HO-1 and H2S pathways for potential treatment for pre-term labor. Acevedo and I had shown that progesterone induced CO production, which could account for its ability to relax the human myometrium. You may want to check if progesterone also leads to H2S production from the myometrium.

No competing interests declared.

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A New Slow Releasing, H₂S Generating Compound, GYY4137 Relaxes Spontaneous and Oxytocin-Stimulated Contractions of Human and Rat Pregnant Myometrium

A New Slow Releasing, H₂S Generating Compound, GYY4137 Relaxes Spontaneous and Oxytocin-Stimulated Contractions of Human and Rat Pregnant Myometrium

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Diatomic gases hold may hold key to therapy

Posted by ahmedas on 27 Apr 2013 at 15:47 GMT