Elicitation of Neutralizing Antibodies Directed against CD4-Induced Epitope(s) Using a CD4 Mimetic Cross-Linked to a HIV-1 Envelope Glycoprotein

Antu K. Dey; Brian Burke; Yide Sun; Klara Sirokman; Avishek Nandi; Karin Hartog; Ying Lian; Anthony R. Geonnotti; David Montefiori; Michael Franti; Grégoire Martin; Andrea Carfi; Pascal Kessler; Loïc Martin; Indresh K. Srivastava; Susan W. Barnett

doi:10.1371/journal.pone.0030233

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Peer-reviewed

Research Article

Elicitation of Neutralizing Antibodies Directed against CD4-Induced Epitope(s) Using a CD4 Mimetic Cross-Linked to a HIV-1 Envelope Glycoprotein

Antu K. Dey,

Affiliation Novartis Vaccines and Diagnostics, Cambridge, Massachusetts, United States of America
⨯
Brian Burke,

Affiliation Novartis Vaccines and Diagnostics, Cambridge, Massachusetts, United States of America
⨯
Yide Sun,

Affiliation Novartis Vaccines and Diagnostics, Cambridge, Massachusetts, United States of America
⨯
Klara Sirokman,

Affiliation Novartis Vaccines and Diagnostics, Cambridge, Massachusetts, United States of America
⨯
Avishek Nandi,

Affiliation Novartis Vaccines and Diagnostics, Cambridge, Massachusetts, United States of America
⨯
Karin Hartog,

Affiliation Novartis Vaccines and Diagnostics, Cambridge, Massachusetts, United States of America
⨯
Ying Lian,

Current address: Gilead Sciences, Foster City, California, United States of America

Affiliation Novartis Vaccines and Diagnostics, Cambridge, Massachusetts, United States of America
⨯
Anthony R. Geonnotti,

Affiliation Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
David Montefiori,

Affiliation Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Michael Franti,

Current address: Boehringer Ingelheim Canada Ltd, Quebec, Canada

Affiliation Novartis Vaccines and Diagnostics, Cambridge, Massachusetts, United States of America
⨯
Grégoire Martin,

Affiliation CEA, iBiTecS, Service d'Ingénierie Moléculaire des Protéines, Gif sur Yvette, France
⨯
Andrea Carfi,

Affiliation Novartis Vaccines and Diagnostics, Cambridge, Massachusetts, United States of America
⨯
Pascal Kessler,

Affiliation CEA, iBiTecS, Service d'Ingénierie Moléculaire des Protéines, Gif sur Yvette, France
⨯
Loïc Martin,

Affiliation CEA, iBiTecS, Service d'Ingénierie Moléculaire des Protéines, Gif sur Yvette, France
⨯
Indresh K. Srivastava,

Current address: VRC/NIAI, Gaithersburg, Maryland, United States of America

Affiliation Novartis Vaccines and Diagnostics, Cambridge, Massachusetts, United States of America
⨯
[ ... ],
Susan W. Barnett

* E-mail: susan.barnett@novartis.com

Affiliation Novartis Vaccines and Diagnostics, Cambridge, Massachusetts, United States of America
⨯
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Elicitation of Neutralizing Antibodies Directed against CD4-Induced Epitope(s) Using a CD4 Mimetic Cross-Linked to a HIV-1 Envelope Glycoprotein

Antu K. Dey,
Brian Burke,
Yide Sun,
Klara Sirokman,
Avishek Nandi,
Karin Hartog,
Ying Lian,
Anthony R. Geonnotti,
David Montefiori,
Michael Franti

Published: January 24, 2012
https://doi.org/10.1371/journal.pone.0030233

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Publisher's Note: Error in Figure 5.

Posted by PLOS_ONE_Group on 09 Apr 2012 at 20:12 GMT

Serum-mapping analysis.
http://plosone.org/article/info:doi/10.1371/journal.pone.0030233#pone-0030233-g005

There was an error in panel A of Figure 5. The correct Figure 5 can be viewed here:
http://www.plosone.org/corrections/pone.0030233.g005.cn.pdf

No competing interests declared.

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Elicitation of Neutralizing Antibodies Directed against CD4-Induced Epitope(s) Using a CD4 Mimetic Cross-Linked to a HIV-1 Envelope Glycoprotein

Elicitation of Neutralizing Antibodies Directed against CD4-Induced Epitope(s) Using a CD4 Mimetic Cross-Linked to a HIV-1 Envelope Glycoprotein

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Publisher's Note: Error in Figure 5.

Posted by PLOS_ONE_Group on 09 Apr 2012 at 20:12 GMT