Carnitine Deficiency in OCTN2−/− Newborn Mice Leads to a Severe Gut and Immune Phenotype with Widespread Atrophy, Apoptosis and a Pro-Inflammatory Response

Srinivas Sonne; Prem S. Shekhawat; Dietrich Matern; Vadivel Ganapathy; Leszek Ignatowicz

doi:10.1371/journal.pone.0047729

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Research Article

Carnitine Deficiency in OCTN2^−/− Newborn Mice Leads to a Severe Gut and Immune Phenotype with Widespread Atrophy, Apoptosis and a Pro-Inflammatory Response

Srinivas Sonne,

Affiliations Department of Pediatrics, Medical College of Georgia, Georgia Health Science University, Augusta, Georgia, United States of America, Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Health Sciences University, Augusta, Georgia, United States of America
⨯
Prem S. Shekhawat ,

* E-mail: shekhawatp@ecu.edu

Affiliations Department of Pediatrics, Medical College of Georgia, Georgia Health Science University, Augusta, Georgia, United States of America, Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Health Sciences University, Augusta, Georgia, United States of America
⨯
Dietrich Matern,

Affiliation Departments of Laboratory Medicine & Pathology, Medical Genetics, and Pediatric & Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
⨯
Vadivel Ganapathy,

Affiliation Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Health Sciences University, Augusta, Georgia, United States of America
⨯
Leszek Ignatowicz

Affiliation Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Georgia Health Sciences University, Augusta, Georgia, United States of America
⨯

Carnitine Deficiency in OCTN2^−/− Newborn Mice Leads to a Severe Gut and Immune Phenotype with Widespread Atrophy, Apoptosis and a Pro-Inflammatory Response

Srinivas Sonne,
Prem S. Shekhawat,
Dietrich Matern,
Vadivel Ganapathy,
Leszek Ignatowicz

Published: October 24, 2012
https://doi.org/10.1371/journal.pone.0047729

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Publisher's Note: Error in Figure

Posted by PLOS_ONE_Group on 03 Jul 2013 at 18:56 GMT

Figure 1 was not labeled correctly. The correct Figure 1 can be viewed here: http://www.plosone.org/co...

The legend for Figure 1 can be found below:

Figure 1. Gut histology of 1-week-old wild type (OCTN2^+/+) and age-matched homozygous (OCTN2^−/−) mice (H&E staining, X20).

Images A–C represent photomicrographs of wild type (OCTN2^+/+) jejunum, ileum and colon respectively and images D–F represent photomicrographs of homozygous (OCTN2^−/−) jejunum, ileum and colon at the same magnification. (Bar represents 50 µm).

No competing interests declared.

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Carnitine Deficiency in OCTN2^−/− Newborn Mice Leads to a Severe Gut and Immune Phenotype with Widespread Atrophy, Apoptosis and a Pro-Inflammatory Response

Carnitine Deficiency in OCTN2^−/− Newborn Mice Leads to a Severe Gut and Immune Phenotype with Widespread Atrophy, Apoptosis and a Pro-Inflammatory Response

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Publisher's Note: Error in Figure

Posted by PLOS_ONE_Group on 03 Jul 2013 at 18:56 GMT