Novel Insulin Sensitizer Modulates Nutrient Sensing Pathways and Maintains β-Cell Phenotype in Human Islets

Nidhi Rohatgi; Haytham Aly; Connie A. Marshall; William G. McDonald; Rolf F. Kletzien; Jerry R. Colca; Michael L. McDaniel

doi:10.1371/journal.pone.0062012

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Peer-reviewed

Research Article

Novel Insulin Sensitizer Modulates Nutrient Sensing Pathways and Maintains β-Cell Phenotype in Human Islets

Nidhi Rohatgi,

Affiliation Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri, United States of America
⨯
Haytham Aly,

Affiliation Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri, United States of America
⨯
Connie A. Marshall,

Affiliation Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri, United States of America
⨯
William G. McDonald,

Affiliation Metabolic Solutions Development Company, Kalamazoo, Michigan, United States of America
⨯
Rolf F. Kletzien,

Affiliation Metabolic Solutions Development Company, Kalamazoo, Michigan, United States of America
⨯
Jerry R. Colca,

Affiliation Metabolic Solutions Development Company, Kalamazoo, Michigan, United States of America
⨯
Michael L. McDaniel

* E-mail: mmcdaniel@wustl.edu

Affiliation Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri, United States of America
⨯

Novel Insulin Sensitizer Modulates Nutrient Sensing Pathways and Maintains β-Cell Phenotype in Human Islets

Nidhi Rohatgi,
Haytham Aly,
Connie A. Marshall,
William G. McDonald,
Rolf F. Kletzien,
Jerry R. Colca,
Michael L. McDaniel

Published: May 1, 2013
https://doi.org/10.1371/journal.pone.0062012

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Media Coverage of this Article

Posted by PLOS_ONE_Group on 03 Jun 2013 at 15:24 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: The Wall Street Journal
Title: “Metabolic Solutions Development Company announces publication of data describing potential for new drugs to maintain pancreatic beta-cells in treating diabetes - WSJ.com”
http://online.wsj.com/art...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS ONE Staff

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Insulin
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Glucose
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Insulin signaling
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DNA synthesis
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Mitochondria
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Gene expression
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Wnt signaling cascade
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Insulin resistance
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Novel Insulin Sensitizer Modulates Nutrient Sensing Pathways and Maintains β-Cell Phenotype in Human Islets

Novel Insulin Sensitizer Modulates Nutrient Sensing Pathways and Maintains β-Cell Phenotype in Human Islets

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Media Coverage of this Article

Posted by PLOS_ONE_Group on 03 Jun 2013 at 15:24 GMT