PhoP: A Missing Piece in the Intricate Puzzle of Mycobacterium tuberculosis Virulence

Jesús Gonzalo-Asensio; Serge Mostowy; Jose Harders-Westerveen; Kris Huygen; Rogelio Hernández-Pando; Jelle Thole; Marcel Behr; Brigitte Gicquel; Carlos Martín

doi:10.1371/journal.pone.0003496

Loading metrics

Open Access

Peer-reviewed

Research Article

PhoP: A Missing Piece in the Intricate Puzzle of Mycobacterium tuberculosis Virulence

Jesús Gonzalo-Asensio,

Affiliations Grupo de Genética de Micobacterias, Departamento de Microbiología, Facultad de Medicina, Universidad de Zaragoza, Zaragoza, Spain, CIBER Enfermedades Respiratorias, Mallorca, Illes Balears, Spain
⨯
Serge Mostowy,

Current address: Unité des interactions Bactéries-Cellules, Institut Pasteur, Paris, France

Affiliation Division of Infectious Diseases and Medical Microbiology, Montreal General Hospital, Montreal, Canada
⨯
Jose Harders-Westerveen,

Affiliation Central Veterinary Institute, Lelystad, The Netherlands
⨯
Kris Huygen,

Affiliation WIV-Pasteur Institute Brussels, Brussels, Belgium
⨯
Rogelio Hernández-Pando,

Affiliation Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition “Salvador Zubiràn”, Mexico City, Mexico
⨯
Jelle Thole,

Affiliation TuBerculosis Vaccine Initiative, Lelystad, The Netherlands
⨯
Marcel Behr,

Affiliation Division of Infectious Diseases and Medical Microbiology, Montreal General Hospital, Montreal, Canada
⨯
Brigitte Gicquel,

Affiliation Unité de Génétique Mycobactérienne, Institut Pasteur, Paris, France
⨯
Carlos Martín

* E-mail: carlos@unizar.es

Affiliations Grupo de Genética de Micobacterias, Departamento de Microbiología, Facultad de Medicina, Universidad de Zaragoza, Zaragoza, Spain, CIBER Enfermedades Respiratorias, Mallorca, Illes Balears, Spain
⨯

PhoP: A Missing Piece in the Intricate Puzzle of Mycobacterium tuberculosis Virulence

Jesús Gonzalo-Asensio,
Serge Mostowy,
Jose Harders-Westerveen,
Kris Huygen,
Rogelio Hernández-Pando,
Jelle Thole,
Marcel Behr,
Brigitte Gicquel,
Carlos Martín

Published: October 23, 2008
https://doi.org/10.1371/journal.pone.0003496

Reader Comments

Post a new comment on this article

AUTHOR SUMMARY

Posted by CarlosMartin on 23 Oct 2008 at 13:15 GMT

Tuberculosis is the leading cause of mortality due to a bacterial infection. The success of Mycobacterium tuberculosis as a pathogen probably resides in its high adaptation to the human host. Understanding the mechanisms by which M. tuberculosis survive within infected cells could help in the design of new
drugs/vaccines against tuberculosis. We have previously studied the potential use of an M. tuberculosis phoP mutant as live attenuated vaccine candidate. In an effort to decipher the molecular basis of attenuation of the phoP mutant, in this study we identify the regulatory network under the control of PhoP. Our results suggest that PhoP regulates key processes for intracellular survival in M. tuberculosis.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Mycobacterium tuberculosis
Is the Subject Area "Mycobacterium tuberculosis" applicable to this article?

Thanks for your feedback.
Regulons
Is the Subject Area "Regulons" applicable to this article?

Thanks for your feedback.
Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.
Gene regulation
Is the Subject Area "Gene regulation" applicable to this article?

Thanks for your feedback.
Respiratory infections
Is the Subject Area "Respiratory infections" applicable to this article?

Thanks for your feedback.
Hypoxia
Is the Subject Area "Hypoxia" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Transcriptome analysis
Is the Subject Area "Transcriptome analysis" applicable to this article?

Thanks for your feedback.

PhoP: A Missing Piece in the Intricate Puzzle of Mycobacterium tuberculosis Virulence

PhoP: A Missing Piece in the Intricate Puzzle of Mycobacterium tuberculosis Virulence

Reader Comments

Post Your Discussion Comment

Why should this posting be reviewed?

Thank You!

AUTHOR SUMMARY

Posted by CarlosMartin on 23 Oct 2008 at 13:15 GMT